Benazepril (HCl)

Drug #1430

Benazepril (HCl) is an angeotensin converting enzyme inhibitor (ACEI). Benazepril (HCl) is a prodrug, converted into benazeprilat which is the active form of the drug. It lowers systemic vascular resistance and mean diastolic, and systolic blood pressure in various hypertensive states. ACE inhibitors have a perticularly useful role in treating patients with diabetic nephropathy. They have also proved to be extremely useful in the treatment of heart failure, and after MI (myocardial infarction).

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Primary Characteristics

It is of Synthetic origin and belongs to Benzapine.

Molecular Weight: 461 · pK_a: 3.1, 5.3 · Solubility in Water: 1 in 13 · Solubility in Alcohol: > 1 in 2 · Non-proprietary name: Benazepril (HCl).

Pharmacokinetics

Absorption: Benazepril (HCl) has an oral bioavailability is 18.5% (±18.5%).

Distribution: Benazepril (HCl) has a volume of distribution is 8.7 liter. plasma protein binding is 92-95%.

Elimination: plasma half-life is 3 hr, renal excretion is > 1% (unchanged).

Indications

Benazepril (HCl) is primarily indicated in conditions like Arterial hypertension, Congestive heart failure.

Contraindications

Benazepril (HCl) is contraindicated in conditions like Angioedema, Hypersensitivity.

Dosage

None recorded.

Drug Interactions

Unknown2 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Benazepril (HCl) produces potentially life-threatening effects which include Sustained tachycardia. Careful monitoring is needed with proper medical management.

Benazepril (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Azotemia, Cough , Dizziness, Fatigue, Headache, Hypotension , Nausea, Somnolence , Vertigo.

Warnings / Precautions

Benazepril should be use carefully in patients of kidney insufficiency, severe liver dysfunction, hypervolemia, angioedema and pre-existing bone marrow depression. Patients with renal artery stenosis should not receive benazepril because renal insufficiency can result from inhibition of the renin-aldosterone system, which maintains GFR in these cases. Other types of renal disease can actually improve during benazepril therapy. The dose of benazepril should be adjusted in patients with renal impairment. Monitoring and dosage adjustments may be necessary in patients with hepatic impairment. Benazepril should be used with caution patients with hyperkalemia, in patients with congestive heart failure. Initial doses should be lower than in the treatment of hypertension because of a greater risk of developing hypotension. Hypotension may aggravate ischemia in patients with coronary artery disease or cerebrovascular disease precipitating a myocardial infarction or cerebrovascular accident. It is classified as pregnancy category C and should be used with caution during pregnancy only if clearly needed.

Available Brands

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Multi-Ingredient Combinations

Tabs

20 mg

Storage Conditions

Benazepril (HCl) should be stored Tab.

Drug Classification

1.12.3.3 — ACE inhibitors

Manufacturers

Manufacturers of Benazepril (HCl) in Pakistan:

Werrick Wilsons