Acipimox

Drug #1419

Acipimox is a lipid regulating drug, belongs to nicotinic acid group. It reduces blood lipid level by inhibiting the release of fatty acids from fat tissues. Acipimox is used for the treatment of hyperlipidaemias of type IIa, IIb and IV in patients not responded adequately to diet and other appropriate measures.

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Primary Characteristics

It is of Synthetic origin and belongs to Carboxylic acid.

Molecular Weight: 154.1 · pK_a: 3.25 · Solubility in Water: 1 in 100 · Solubility in Alcohol: < 1 in 1000 · Non-proprietary name: Acipimox.

Pharmacokinetics

Absorption: Acipimox has an oral bioavailability is 45% (±45%).

Distribution: Acipimox has a volume of distribution is 0.3-0.4 l/kg. plasma protein binding is negligible.

Elimination: plasma half-life is 0.8-2.4 hr, renal excretion is 90% (unchanged).

Indications

Acipimox is primarily indicated in conditions like Hypertriglyceridaemia.

Contraindications

Acipimox is contraindicated in conditions like Peptic ulcer, Hypersensitivity.

Dosage

Acipimox's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
625 mg/day	625 mg/day	—	PO	In particular the lower dose is advised in type IV and the higher dose in types IIa and IIb hyperlipoproteinaemias. Daily dose should be divided and taken with main meals.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Acipimox produces potentially life-threatening effects which include Bronchospasm , Bronchospasm, Angioedema , Anaphylactic reactions. Careful monitoring is needed with proper medical management.

Acipimox is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Dry eye, Epigastric pain, Flushing, Headache, Heart burn, Itching, Malaise, Nausea, Rashes , Urticaria.

Warnings / Precautions

Avoid drinking alcohol during treatment with acipimox. If you buy any medicines, check with a pharmacist that they are safe to take with acipimox.

Available Brands

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Single Ingredient

Caps

250 mg

Storage Conditions

Acipimox should be stored Caps.

Drug Classification

1.12.6 — Lipid-regulating drugs /Anti-atheromas

Manufacturers

Manufacturers of Acipimox in Pakistan:

Pacific