Cefotetan

Drug #141

Cefotetan is a second generation, semisynthetic, ß lactamase resistant cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cefotetan is a broad spectrum antibiotic effective against a wide range of gram positive, gram negative and anaerobic bacterias. Cefotetan is less effective against gram positive bacterias than first generation drugs. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefotetan is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Cephamycin.

It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.

Molecular Weight: 619.56 · pK_a: 2.1 · Solubility in Water: 1 in 100-1000 · Solubility in Alcohol: 1 in 100-1000 · Non-proprietary name: Cefotetan.

Pharmacokinetics

Distribution: Cefotetan has a volume of distribution is 8-13 litre. plasma protein binding is 88%.

Elimination: plasma half-life is 2.8-4 hr, renal excretion is 67%.

Indications

Cefotetan is primarily indicated in conditions like Dental infections, Ent infections, Gonorrhoea, Intra-abdominal infections, Obstetric and gynaecological infections, Respiratory tract infections, Septicaemia, Skin infections, Soft tissue infections, UTI.

Contraindications

Cefotetan is contraindicated in conditions like Meningitis.

Dosage

Cefotetan's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
14.28 mg/kg	14.28 mg/kg	Every 12h	IM	-
14.28 mg/kg	14.28 mg/kg	Every 12h	IV	-
Paediatric Dosage (20kg)
20 mg/kg	20 mg/kg	Every 12h	Intra Venous	-
Neonatal Dosage (3kg)
20 mg/kg	20 mg/kg	Every 12h	Intravenous	Dose for children above 6 months

Drug Interactions

Unknown2 interactions

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Cefotetan in overdosage may give rise to further complications which include Angioedema , Increased prothrombin time , Candidal superinfection , Rashes, Leucopenia, Fever , Erythema , Dermatitis , Urticaria , Positive coombs test , Abnormal LFT, Thrombocytopenia , Eosinophilia .

Cefotetan is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Nausea and vomiting, Phlebitis .

Warnings / Precautions

Cefotetan should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs. It should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma).

Interference in Pathology

Cefotetan may interfere in the diagnosis of Clinitest copper-reduction method for determining glucose concentration in urine. , Alkaline Picrate Assay. .

Available Brands

None recorded.

Storage Conditions

Cefotetan should be stored Inj (reconstituted soln). Powder for Inj. Prefrozen Inj. Thawed .

Drug Classification

1.6.2.1.3 — Cephalosporins