Cefamandole (Na)

Drug #138

Cefamandole is a second generation cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cefamandole is used to treat a large variety of bacterial infections, Cefamandole (Na) is less effective against gram positive bacteria than first generation drugs. Cefamandole (Na) is usually given for surgical infection prophylaxis. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefamandole (Na) is important to take the drug for the full time period as prescribed. If you discontinue the therapy it may result in ineffective treatment.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Cephalosporin.

It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin-2nd Gen pharmacological group.

Molecular Weight: 512.5 · pK_a: 2.46 · Solubility in Water: soluble · Non-proprietary name: Cefamandole (Na).

Pharmacokinetics

Absorption: Cefamandole (Na) has an oral bioavailability is 5% (±5%).

Distribution: Cefamandole (Na) has a volume of distribution is 17.9 litre. plasma protein binding is 65-74%.

Elimination: plasma half-life is 0.5-1.5 hr.

Indications

Cefamandole (Na) is primarily indicated in conditions like Bone and joint infection, Cholecystitis, Peritonitis, Respiratory tract infections, Septicaemia, Skin infections, Soft tissue infections, Surgical prophylaxis, Urinary tract infection.

Contraindications

Cefamandole (Na) is contraindicated in conditions like Hypersensitivity.

Dosage

Cefamandole (Na)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1250 mg	1250 mg	Every 8h	IV,IM
Paediatric Dosage (20kg)
33.33 mg/kg	33.33 mg/kg	Every 8h	Intra Muscular	-
33.33 mg/kg	33.33 mg/kg	Every 8h	Intra Venous	-
Neonatal Dosage (3kg)
33.33 mg/kg	33.33 mg/kg	Every 8h	Intramuscular	Not recommended under 1 month peds
33.33 mg/kg	33.33 mg/kg	Every 8h	Intrvenous	Not recommended under 1 month Peds

Drug Interactions

Unknown2 interactions

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Cefamandole (Na) in overdosage may give rise to further complications which include Maculopapular rash , Eosinophilia , Hypersensitivity reactions , Drug fever , Thrombophlebitis , Urticaria , Phlebitis.

Cefamandole (Na) is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Nausea, Vomiting .

Warnings / Precautions

Cefamandol should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs. It should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma).

Interference in Pathology

Cefamandole (Na) may interfere in the diagnosis of False +ve reaction for glucose in urine with Benedicts or Fehlings or Clinitest Tabs. , False +ve results for proteinuria using acid and denaturization precipation test. .

Available Brands

None recorded.

Storage Conditions

Cefamandole (Na) should be stored Inj.

Drug Classification

1.6.2.1.3 — Cephalosporins