Famciclovir
Also known as: Famsitlorin, Famcicrourium
Famciclovir is antiviral agent. Famciclovir is a diacetyl ester prodrug of 6-deoxy penciclovir, an acyclic guanosine derivative. Famciclovir is active against herpes simplex virus 1 and 2, varicella zoster virus and hepatitis B virus.
Primary Characteristics
Famciclovir is also known as Famsitlorin, Famcicrourium.
It is of Synthetic origin.
Molecular Weight: 321.3 · Non-proprietary name: Famciclovir.
Pharmacokinetics
Absorption: Famciclovir has an oral bioavailability is 70%.
Distribution: Famciclovir has a plasma protein binding is 20 %.
Elimination: it is metabolised via Liver, plasma half-life is 10 hrs.
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Indications
Famciclovir is primarily indicated in conditions like Genital herpes, Herpes simplex infections, Herpes zoster, Recuurent infection, Treatment of herpes zoster, Varicella zoster infections.
Contraindications
None recorded.
Dosage
Famciclovir's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 250 mg | 250 mg | Every 12h | PO | Suppression of Recurrent Genital Herpes should be given for 1 year. |
| 500 mg | 500 mg | Every 12h | PO | For recurrent orolabial or genital herpes simplex infection,should be given for 7 days. |
| 500 mg | 500 mg | Every 24h | PO | For herpes zoster infection. |
| 1000 mg | 1000 mg | Every 12h | PO | For Recurrent Genital Herpes |
| 1500 mg | 1500 mg | — | PO | Recurrent Herpes Labialis (Cold Sores) |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Famciclovir in overdosage may give rise to further complications which include Hallucinations , Hallucinations , Granulocytopenia .
Famciclovir is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Confusion, dizziness, Dyspepsia , Fatigue, Fever, Hallucination , Headache, Jaundice , Nausea and vomiting, Skin rashes.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.6.5.1 — Herpes and cytomegalovirus infection