Gadodiamide

Drug #1303

Gadodiamide is a non-ionic paramagnetic agent. Gadodiamide is used for enhancement in imaging of cranial and spinal structures.

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Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 573.1 · Solubility in Water: Freely Soluble · Non-proprietary name: Gadodiamide · pH: 5.5.

Pharmacokinetics

Distribution: Gadodiamide has a volume of distribution is 3.7±2.7. plasma protein binding is not bound.

Elimination: plasma half-life is 77.8±16, renal excretion is 96%(unchanged).

Indications

Gadodiamide is primarily indicated in conditions like Diagnostic procedures, Non ionic contrast medium.

Contraindications

Gadodiamide is contraindicated in conditions like Anaemia, Asthma, Hypersensitivity to the drug.

Dosage

Gadodiamide's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
0.2 ml/kg body weight	0.2 ml/kg body weight	—	IV
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Gadodiamide in overdosage may give rise to further complications which include Hypotension , Hypotension , Paresthesia, Transient elevation of serum iron & bilirulin, Localized Pain.

Gadodiamide produces potentially life-threatening effects which include Shock . Careful monitoring is needed with proper medical management.

Gadodiamide is known to cause more or less tolerable side effects which are usually transient. These include Allergic reactions, Dizziness, Headache, Nausea and vomiting, Pain , Sensation of warmth, Taste disturbance.

Warnings / Precautions

The usual precaution measures for MRI examination should be taken, such as exclusion of pacemakers and ferro-magnetic implants.To enable immediate action in emergencies, the necessary medicinal products and equipment for intubation and adequate ventilation support must be immediately available. If hypersensitivity reactions occur, the administration of the contrast medium must be discontinued immediately.

Interference in Pathology

Gadodiamide may interfere in the diagnosis of May Interfere with colorimetric methods for measuring serum calcium consentunations, resulting in falsely low measurnments..

Available Brands

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Single Ingredient

Inj

287 mg/0.5mmol

Storage Conditions

Gadodiamide should be stored IV Inj.

Drug Classification

1.14.2 — Radiocontrast media

Manufacturers

Manufacturers of Gadodiamide in Pakistan:

Meximp