Sodium Diatrizoate

Also known as: Amidotrizoate, Diatrizoate, Iothalamate , Triombrin

Drug #1252

Sodium Diatrizoate used in diagnostic radiography.

Primary Characteristics

Sodium Diatrizoate is also known as Amidotrizoate, Diatrizoate, Iothalamate , Triombrin .

It is of Synthetic origin and belongs to Methylglucamine sodium.

Molecular Weight: 635.9 · Solubility in Water: 89 in 100 · Solubility in Alcohol: low · Non-proprietary name: Sodium Diatrizoate.

Molecular structure of Sodium Diatrizoate

Pharmacokinetics

Distribution: Sodium Diatrizoate has a volume of distribution is 19.5% body weight. plasma protein binding is < 5%.

Elimination: plasma half-life is 100 min, renal excretion is 95% (24 hrs).

Indications

Sodium Diatrizoate is primarily indicated in conditions like Angiography, Arthrography, CT enhancement, Excretion urography, Splenoportography, Venography.

Contraindications

Sodium Diatrizoate is contraindicated in conditions like Asthma, Phaeochromocytoma, Myeloma, Renal impairment, Sickle cell disease.

Dosage

Sodium Diatrizoate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
135 mL	135 mL	—	PO	90-180 mL of a 25 to 40 percent solution.
750 mL	750 mL	—	PO	Enema, from 500 mL to 1000 mL of a 15 to 25 percent solution.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Sodium Diatrizoate in overdosage may give rise to further complications which include Bradycardia , Renal impairment , Tachycardia , Pancreatitis .

Sodium Diatrizoate produces potentially life-threatening effects which include Pulmonary edema , Cardiac arrhythmia, Bronchospasm , Angioneurotic edema, Hypertensive crises, Anaphylactic reactions. Careful monitoring is needed with proper medical management.

Sodium Diatrizoate is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Faintness , Flushing, Headache, Metallic taste, Nausea, Sensation of warmth, Sweating , Taste disturbances, Vomiting , Weakness.

Warnings / Precautions

It should be used with caution in patients with previous reaction to diatrizoates or any other iodinated contrast agent and patient with allergies to other drugs. Diatrizoate should be administered with great caution in patients with asthma and history of allergy, and should be avoided to patients with known hypersensitivity to iodine or contrast media. An IV injection of 0.5 to 1 ml of contrast media has been given as a test for sensitivity before administration of main dose. Caution is needed in patients with severe hepatic (liver) or renal impairment or who may be at a risk of renal failure. Dehydration patients should have their fluid and electrolyte balance corrected before administration of contrast medium. It should be used with extreme caution in patients with hypertension, cardiac disease, phaeochromocytoma, sickle-cell anemia or hypothyroidism. Avoid use during pregnancy.

Available Brands

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Multi-Ingredient Combinations

Soln

10 g/ml

Storage Conditions

Sodium Diatrizoate should be stored Soln .

Drug Classification

1.14.2 — Radiocontrast media

Manufacturers

Manufacturers of Sodium Diatrizoate in Pakistan:

Bayer