DrugInfoSys

Meclizine

Also known as: Meclozine, Parachloramine HCl

Drug #1246

Meclizine is a piperazine derivative, is a sedating anti-histimine with antimuscarinic properties. Meclizine is mainly used for its antiemetic action which may last for up to 24 hours. Meclizine is used in the prevention and treatment of nausea and vomiting associated with variety of conditions including motion sickness and for symptomatic treatment of vertigo and Meclizine is also used for the symptomatic relief of hypersensitivity reactions and pruritic skin disorders.

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Primary Characteristics

Meclizine is also known as Meclozine, Parachloramine HCl.

It is of Synthetic origin and belongs to Piperizine dervative.

Molecular Weight: 390.95 · Solubility in Water: Insoluble · Solubility in Alcohol: Slightly soluble · Non-proprietary name: Meclizine.

Molecular structure of Meclizine

Pharmacokinetics

Elimination: plasma half-life is 6 hr.

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Indications

Meclizine is primarily indicated in conditions like Dizziness, Motion sickness, Nausea and vomiting, Vertigo, Vestibular disturbances.

Contraindications

Meclizine is contraindicated in conditions like Hypersensitivity to any component of product.

Dosage

Meclizine's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
25 – 50 mg—Every 8hPOOnce hour before travelling & repeated every 24 hour if necessary up to 100mg.
Paediatric Dosage (20kg)
6.25 mg6.25 mgEvery 24h2-6
12.5 mg12.5 mgEvery 24h6-12 years.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Meclizine in overdosage may give rise to further complications which include Tachycardia , Palpitation , Urinary retention, Visual hallucination .

The signs and symptoms that are produced after acute overdosage of Meclizine are Respiratory paralysis, Convulsions , Hallucinations .

Meclizine is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Blurred vision, Diarrhea, Drowsiness, Dry mouth, Insomnia, Nausea and vomiting, nervousness, Rashes .

Warnings / Precautions

Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness. Meclizine should be used with caution in patients with asthma, glaucoma, obstructive disease of gastrointestinal (GI) tract.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Dry Susp
80 mg/0.8ml

Multi-Ingredient Combinations

Drops
80 mg/0.8ml
Tabs
25 mg

Storage Conditions

Meclizine should be stored Tab.

Drug Classification

  1. 1.17.2 — Antiemetics & antinauseants

Manufacturers

Manufacturers of Meclizine in Pakistan:

BloomGSKTFC PHARMAWebrose