Cannabis

Drug #124

Cannabis is the dried flowering tops of the hemp plants it sativa. The three major cannabinoids have been found in it, cannabidiol (CBD), tetrahydrocannabinol (THC) and cannabinol (CBN). The use of the it has been recorded for thousands of years, especially in Eastern countries such as China and India. It was certainly known to the Greeks at the height of their civilization as well as to the Arabic nations somewhat later. Cannabis is estimated that about 200-300 million peoples use it in some form. Cannabis is not only one of the oldest drug but also one of the most widely used of mind altering drugs. Cannabis is classidied as a hallucinogenic and is prepared as bhang, ganja, hashish and marijuana.

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Primary Characteristics

It is of Natural origin and belongs to Benzopyran.

It belongs to Hallucinogen pharmacological group on the basis of mechanism of action and also classified in Antiemetic pharmacological group. It is also classified under Sedatives and Hypnotics .

Molecular Weight: 314.5 · Solubility in Water: insoluble · Solubility in Alcohol: soluble · Non-proprietary name: Cannabis.

Pharmacokinetics

Absorption: Cannabis has an oral bioavailability is 5% (±5%).

Distribution: Cannabis has a plasma protein binding is 97%.

Elimination: plasma half-life is 20-36 hr.

Indications

Cannabis is primarily indicated in conditions like Anorexia, Asthma, Convulsions, Emesis, Glucoma, Insomnia.

Contraindications

Cannabis is contraindicated in conditions like Ischaemic heart disease, Pregnancy.

Dosage

Cannabis's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.035 mg/kg	0.035 mg/kg	Every 12h	PO	-
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—	—	Not Recommended in this Age Group

Drug Interactions

Unknown3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Cannabis in overdosage may give rise to further complications which include Flashbacks , Panic attacks .

Cannabis is known to cause more or less tolerable side effects which are usually transient. These include Dry mouth, Postural hypotension, Psychosis, Tachycardia, Tremor.

Warnings / Precautions

Avoid cannabis during pregnancy. Avoid large doses of cannabis. Patients should observe caution while driving or performing tasks requiring alertness, because it may cause deterioration in motor co-ordination.

Available Brands

None recorded.

Storage Conditions

Cannabis should be stored Cap.

Drug Classification

1.24.3 — Drugs used in anxiety and sleep disorders