Cisapride

Drug #1236

Cisapride is a substituted benzamide. Cisapride is used to treat symptoms and lesions of heartburn due to gastric-oesophageal reflux disease.

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Primary Characteristics

It is of Synthetic origin and belongs to Benzamide.

Molecular Weight: 484 · pK_a: 9100 · Solubility in Water: < 1 in 10000 · Solubility in Alcohol: null · Non-proprietary name: Cisapride.

Pharmacokinetics

Absorption: Cisapride has an oral bioavailability is 95%, pre-systemic (first-pass) metabolism accounts for 55% (±5%).

Distribution: Cisapride has a volume of distribution is 2.4 l/kg. plasma protein binding is 98%.

Elimination: it is metabolised via extensively through liver, plasma half-life is 7-10 hr, renal excretion is 44% in 24 hr.

Indications

Cisapride is primarily indicated in conditions like Delayed gastric emptying, Dyspepsia, Gastro-esophageal reflux disease, GI motality disorder.

Contraindications

Cisapride is contraindicated in conditions like Intestinal obstruction.

Dosage

Cisapride's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
10 mg	10 mg	Every 6h	PO	Should be taken 15 min before meals and bed time.
10 ml	10 ml	Every 6h	PO	Should be taken 15 min before meals and bed time.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown16 interactions

7 interactions

Major8 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Cisapride in overdosage may give rise to further complications which include Cardiac arrhythmias, Asthma .

Cisapride produces potentially life-threatening effects which include Torsades de pointes. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Cisapride are Ventricular arrhythmias, Diarrhea, Abdominal cramps, Q.T interval prolongation.

Cisapride is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Borborygmi, Diarrhea, Dizziness, Headache.

Warnings / Precautions

Cisapride should be used with caution in patients with any pre-existing intestinal disorders, bleeding ulcers, asthma, kidney or heart problems or any allergy. This medication should be used only if clearly needed during pregnancy or lactation.

Available Brands

None recorded.

Storage Conditions

Cisapride should be stored Tab, Susp .

Drug Classification

1.17.1.2 — Anti-peptic ulcerants