Calcium Gluconate
Also known as: Calcium Glyconate
Calcium Gluconate is used as a source of calcium in deficiency states. Calcium is a mineral which is required for the development and maintenance of healthy bones and teeth, for normal functioning of nerves, cells, muscles and the heart. its supplements are used to ensure proper intake of calcium during bone development in childhood, during pregnancy and breast-feeding. Calcium prevents development of osteoporosis ( bone thinning).
Primary Characteristics
Calcium Gluconate is also known as Calcium Glyconate.
It is of Synthetic origin and belongs to Calcium salt.
It belongs to Minerals and Electrolytes pharmacological group on the basis of mechanism of action and also classified in Calcium Salt pharmacological group.
Molecular Weight: 448.4 · Solubility in Water: 1 in 30 · Solubility in Alcohol: insoluble · Non-proprietary name: Calcium Gluconate.
Pharmacokinetics
Absorption: Calcium Gluconate has an oral bioavailability is 30%.
Distribution: Calcium Gluconate has a plasma protein binding is 50%.
Elimination: renal excretion is 25-45%.
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Indications
Calcium Gluconate is primarily indicated in conditions like Cardiopulmonary bypass, Cardiopulmonary resuscitation, Hyperkalaemia, Hypocalcaemia, Latrodectism, Osteoporosis prophylaxis, Verapamil induced hypotension, Verapamil poisoning.
Calcium Gluconate is also indicated for secondary conditions like Abortion, Hydrofluoric acid burns, Prevention of succinyl-induced myalgia.
Contraindications
Calcium Gluconate is contraindicated in conditions like Hypercalcaemia, Hypercalciuria.
Dosage
Calcium Gluconate's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.75 g | 0.75 g | Every 8h | PO | |
| Paediatric Dosage (20kg) | ||||
| 100 mg/kg | 100 mg/kg | Every 6h | Oral | Single Dose |
| Neonatal Dosage (3kg) | ||||
| 100 mg/kg | 100 mg/kg | Every 6h | Intravenous | Single dose |
| 100 mg/kg | 100 mg/kg | Every 6h | Oral | Single Dose |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Calcium Gluconate in overdosage may give rise to further complications which include Cardiac arrhythmias, Nephrocalcinosis , Renal calculi , Soft tissue calcification .
Calcium Gluconate produces potentially life-threatening effects which include Coma, Cardiac Arrest . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Calcium Gluconate are Hypercalcemia.
Calcium Gluconate is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Bone pain, Confusion, Constipation , Drowsiness, Dry mouth, GI irritation, Local reactions, Muscle weakness, Nausea, Polyuria, Syncope , Thirst, Vomiting .
Warnings / Precautions
Available Brands
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Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.27 — Vitamins, minerals, tonics, and other susbstances