Azelastine (HCl)

Drug #1208

Azelastine (HCl) is antihistamine. Histamine mediate allergic and inflammatory reactions. Azelastine (HCl) is used to relieve symptoms related to allergic rhinitis. Antihistamine nasal spray is used for symtomatic relief of allergic rhinitis. By this route drug does not cause sedation although nasal irritation and taste dsturbance may occur.

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Primary Characteristics

It is of Synthetic origin and belongs to Chlorophenyl Phthalazinone.

Molecular Weight: 418.4 · pK_a: 9.5 · Solubility in Water: 1 in 160 · Solubility in Alcohol: slightly soluble · Non-proprietary name: Azelastine (HCl).

Pharmacokinetics

Absorption: Azelastine (HCl) has an oral bioavailability is 85%, pre-systemic (first-pass) metabolism accounts for 0.5% (±0.5%).

Distribution: Azelastine (HCl) has a plasma protein binding is low.

Elimination: it is metabolised via extensively by liver, plasma half-life is 16.5 hr, renal excretion is partial.

Indications

Azelastine (HCl) is primarily indicated in conditions like Allergic rhinitis, Asthma, Bronchitis.

Azelastine (HCl) is also indicated for secondary conditions like Allergy.

Contraindications

Azelastine (HCl) is contraindicated in conditions like Hypersensitivity.

Dosage

Azelastine (HCl) 's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.1 %	0.1 %	Every 12h	Intra Nasal	For each nostril, As Required
5 mg	5 mg	Every 12h	PO
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recomended in his age group

Drug Interactions

3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Azelastine (HCl) in overdosage may give rise to further complications which include Drowsiness .

The signs and symptoms that are produced after acute overdosage of Azelastine (HCl) are Drowsiness, Convulsions , Excitation .

Azelastine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Drowsiness, Dry mouth, Skin rashes, Tiredness .

Warnings / Precautions

Azelastine should be used with caution in patients with kidney, heart or liver disease, any allergy or high blood pressure. This medication should be used only when clearly needed during pregnancy or lactation.

Available Brands

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Single Ingredient

Nasal Spray

0.14 mg/actu

Storage Conditions

Azelastine (HCl) should be stored Aerosol.

Drug Classification

1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis
2.21.6 — Non-specific anticonjunctivitis preparations
3.25.4 — Nasal preparations

Manufacturers

Manufacturers of Azelastine (HCl) in Pakistan:

Sante