Immune Globulin
Immune Globulin is a concentrate of antibodies of human plasma. Immune Globulin is used to increase the immunity to some viral infections (like hepatitis, measles and rubella) and increases the body's natural immune response in persons with a compromised immune system and Immune Globulin is also used to increase blood count in persons with idiopathic thrombocytopenic purpura (decrease counts of platelets). Immune Globulin are produced by B lymphocytes in response to foriegn antigens.
Primary Characteristics
It is of Semi Synthetic origin and belongs to Protein.
It is classified in Immune Globulin pharmacological group.
Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Immune Globulin · pH: 6.4.
Pharmacokinetics
Elimination: plasma half-life is 23 days (I/M), 21 - 24 days (I/V).
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Indications
Immune Globulin is primarily indicated in conditions like Autoimmune disease, Hepatitis, Idiopathic thrombocytopenic purpura, Measles.
Contraindications
Immune Globulin is contraindicated in conditions like Thrombocytopenia, Ig a deficiency.
Dosage
Immune Globulin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 500 mg/kg | 500 mg/kg | — | Every 3 to 4 weeks. | |
| 600 mg/kg | 600 mg/kg | — | IV | Once in a Month or As Required. Then 200mg/kg every 3 to 4 week. |
| Paediatric Dosage (20kg) | ||||
| 150 mg | 150 mg | — | IM | Once in a Month or As Required. Under 1 year or less children |
| Neonatal Dosage (3kg) | ||||
| 4 mg/kg | 4 mg/kg | Every 24h | Intravenous | For 2---5 days |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Immune Globulin is known to cause more or less tolerable side effects which are usually transient. These include Angioedema, Chills, Erythema, Facial flushing, Fever, Flushing, Headache, Hypersensitivity , Muscle stiffiness, Myalgia, Nausea, Pain , Tenderness , Urticaria, Vomiting .
Warnings / Precautions
Interference in Pathology
Immune Globulin may interfere in the diagnosis of Positive serological testing result.
Available Brands
Storage Conditions
Drug Classification
- 1.19.2.4 — Normal immunoglobulins (human)