Hydroxyzine
Also known as: hydroxzine-pamoate
Hydroxyzine is a synthetic drug with central nervous sytem depressant, antispasmodic, antihistaminic and antifibrillatory actions. Hydroxyzine is administered orally or intramuscularly.
Primary Characteristics
Hydroxyzine is also known as hydroxzine-pamoate, Hydroxyzine Dihydrochloride.
It is of Synthetic origin and belongs to Piperazine.
It is classified in Antiemetic pharmacological group. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 374.9 · Solubility in Water: 1 in 1 · Solubility in Alcohol: 1 in 4.5 · Non-proprietary name: Hydroxyzine.
Pharmacokinetics
Elimination: plasma half-life is 20 hr.
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Indications
Hydroxyzine is primarily indicated in conditions like Anxiety, Insomnia, Pruritus, Tension, Urticaria.
Hydroxyzine is also indicated for secondary conditions like Antiemetic poisoning, Routine management of the 3rd stage of labour, Surgical procedures.
Contraindications
None recorded.
Dosage
Hydroxyzine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 25 – 100 mg | — | Every 24h | IM | Per dose every 4-6 hour as needed |
| 25 mg | 25 mg | Every 24h | PO | At night initialy. |
| Paediatric Dosage (20kg) | ||||
| 0.75 mg/kg | 0.75 mg/kg | Every 6h | Oral | - |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Hydroxyzine in overdosage may give rise to further complications which include Hemolysis .
Hydroxyzine produces potentially life-threatening effects which include Arrhythmias. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Hydroxyzine are Hypotension.
Hydroxyzine is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Dizziness, Drowsiness, Fatigue, Headache, Nervousness, Paresthesias, Seizures and convulsions, Termors, Thickning of bronchial reaction, Xerostomia .
Warnings / Precautions
Available Brands
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Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis
- 2.24.3 — Drugs used in anxiety and sleep disorders