DrugInfoSys

Halofantrine (HCl)

Drug #1146

Halofantrine (HCl) is a phenanthreneSmethanol compound. Halofantrine (HCl) is antimalarial agent. Halofantrine (HCl) is effective against asexual forms of the plasmodium in the blood stream. its use is restricted to the treatment of infection with chloroquine and multidrug resistant Plasmodium falciparum.

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Primary Characteristics

It is of Synthetic origin and belongs to Phenanthrenes.

It is classified in Antimalarial Agent pharmacological group.

Molecular Weight: 536.9 · pKa: 9.7 · Solubility in Water: <1 in 10000 · Solubility in Alcohol: Sparingaly soluble · Non-proprietary name: Halofantrine (HCl).

Molecular structure of Halofantrine (HCl)

Pharmacokinetics

Distribution: Halofantrine (HCl) has a volume of distribution is 570 l/kg.

Elimination: it is metabolised via Hepatic, plasma half-life is 1-4 days.

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Indications

Halofantrine (HCl) is primarily indicated in conditions like Chloroquine resistant malaria, Malaria caused by plasmodium falciparum, Malaria caused by plasmodium vivax.

Contraindications

Halofantrine (HCl) is contraindicated in conditions like Cardiac arrhythmia, Hypersensitivity.

Dosage

Halofantrine (HCl)'s dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
500 mg500 mgEvery 8hPOOr 1500mg divided into 3 doses given at 6 Hourly intervals Empty stomach
Paediatric Dosage (20kg)
8 mg/kg8 mg/kg—Oral 6 Hourly for 3 Doses
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown18 interactions
1 interaction
Major3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Halofantrine (HCl) in overdosage may give rise to further complications which include Ventricular arrhythmia.

Halofantrine (HCl) produces potentially life-threatening effects which include Acute intravenous, haemolysis. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Halofantrine (HCl) are Q.T interval prolongation.

Halofantrine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Diarrhea, Nausea, Pain , Pruritus , Skin rashes, Vomiting .

Warnings / Precautions

It should be avoided inpregnancy & breast feeding.The drug has been shows to produce a dose related prolongation of the QTc interval, even at the recommended dosage , this is usually reversible during 3-4 days. Therefore, this drug is not recommended in pateints, with known QTc prolongation, receiving drugs or having clinical conditions known to prolong QTc interval, with ventricular arrhythmias, sometimes associated with death. Because of the dose-related nature of the effect on the Qtc interval, caution should be taken to avoid increased blood levels that may be associated with higher than recommended doses or increased absorption with fatty foods. It is essential to avoid fatty foods for 24 hrs. It should be not be taken on a full stomach. This increases its bioavailability & risk of toxicity. Fatty food should be avoid 24 hours.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Susp
100 mg/5ml
Tabs
250 mg

Storage Conditions

Halofantrine (HCl) should be stored Tab.

Drug Classification

  1. 1.6.4.3 — Antimalarials

Manufacturers

Manufacturers of Halofantrine (HCl) in Pakistan:

GSKMediateObsons