Cabergoline

Drug #114

Cabergotune is ergot derivatives is a dopamine D2-agonist with action and uses similar to bromocriptine. Cabergoline is used after pregnancy to suppress unwanted breast milk secretion and to facilitate conception when infertility is associated with high prolactin level. It may also be used in parkinson's disease, prolactin-producing tumors and to adjust various hormone levels in certain diseases (ovarian diseases).

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Primary Characteristics

It is of Synthetic origin and belongs to Ethylurea.

It belongs to D2 agonist pharmacological group on the basis of mechanism of action. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 451.6 · Solubility in Water: insoluble · Solubility in Alcohol: soluble · Non-proprietary name: Cabergoline.

Pharmacokinetics

Distribution: Cabergoline has a plasma protein binding is 41-42%.

Elimination: plasma half-life is 62-91 hr, renal excretion is 1.92%.

Indications

Cabergoline is primarily indicated in conditions like Excesssive prolactin level, Lactation inhibition, Parkinson's disease.

Contraindications

Cabergoline is contraindicated in conditions like Peptic ulcer, Hepatic insufficiency, Raynaud's syndrome, Hypersensitivity.

Dosage

Cabergoline's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0 – 0 0	—	—	PO	prevention of lactation 1mg as single dose: suppression of established lactation 250 mcg every 12 hrs for 2 days
0 – 0 0	—	—	PO	Hyperprolacdinaemic disorders: (0.25-2 mg weekly)
1 mg/day	1 mg/day	—	PO	For parkinson''s disease: Increase by increments of 0.5-1 mg at 7-14 day interval. Man 3 mg/day.
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown3 interactions

6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Cabergoline in overdosage may give rise to further complications which include Orthostatic hypotension .

Cabergoline is known to cause more or less tolerable side effects which are usually transient. These include Ankle edema, Confusion, dizziness, Fatigue, Nausea, Vomiting .

Warnings / Precautions

Cabergoline should be used with caution in patients with medical history, including any allergies (especially drug allergies), liver disease, psychiatric illness, uncontrolled high blood pressure or high blood pressure during pregnancy. Limit alcohol as it may aggravate side effects of this drug. Patients should observe caution while driving or performing tasks requiring alertness. To avoid dizziness and lightheadedness when rising from a seated or lying position, get up slowly. It should be used with caution during pregnancy. It is not recommended during lactation.Reduce dose is severe hepatic impairment

Available Brands

None recorded.

Storage Conditions

Cabergoline should be stored Tab.

Drug Classification

1.9.1 — Drugs used in parkinsonism
2.18.6 — Ovulation stimulants