Flunarizine (HCl)

Drug #1122

Flunarizine (HCl) is a sedating antihistamine and difluorinated derivative of cinnarizine. Flunarizine (HCl) is investigational calcium channel blocker. It has been reported in preliminary trials to effectively reduce the severity of the acute attack of migraine and prevent recurrences.

← Previous drug Next drug →

Primary Characteristics

It is of Synthetic origin and belongs to Piperazine.

It belongs to Calcium L-channel antagonist pharmacological group on the basis of mechanism of action and also classified in Vasodilators pharmacological group.

Molecular Weight: 477.4 · pK_a: 7.7 · Solubility in Water: 1 in 300 · Solubility in Alcohol: 1 in 200 · Non-proprietary name: Flunarizine (HCl).

Molecular structure of Flunarizine (HCl)

Pharmacokinetics

Absorption: Flunarizine (HCl) has an oral bioavailability is 47.5% (±47.5%).

Distribution: Flunarizine (HCl) has a volume of distribution is 43 l/kg. plasma protein binding is 90%.

Elimination: it is metabolised via extensive by Liver, plasma half-life is 18 days.

Indications

Flunarizine (HCl) is primarily indicated in conditions like Dizziness, Migraine prophylaxis, Tinnitus, Vertigo.

Contraindications

Flunarizine (HCl) is contraindicated in conditions like Depressive illness, Symptomatic parkinsonism, Hypersensitivity to the drug.

Dosage

Flunarizine (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
5 – 10 mg	—	Every 24h	PO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Flunarizine (HCl) produces potentially life-threatening effects which include Tremour, Rigidity, Orofacial dyskineria, Blady kinesia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Flunarizine (HCl) are Sedation , Asthenia.

Flunarizine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Asthenia , Diarrhea, Drowsiness, Dry mouth, Headache, Heart burn, Nausea.

Warnings / Precautions

Patients should observed caution while driving or performing other tasks requiring alertness, because may cause drowsiness. Flunarizine should be used with caution in patients with liver impairment, dose should be reduced in patients with renal impairment. Avoid use in young children and use with caution in elderly patients.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps

10 mg 5 mg

Storage Conditions

Flunarizine (HCl) should be stored .

Drug Classification

1.7.2 — Migraine prophylaxis

Manufacturers

Manufacturers of Flunarizine (HCl) in Pakistan:

Amarant Janssen-Cilag Panacea Polyfine