Trandolapril

Drug #1082

Trandolapril is oral, non-sulfhydryl-containing angiotensin converting enzyme inhibitor (ACEI). Trandolapril is a prodrug for itat which is about 8 times as potent as it in inhibiting ACE. It blocks the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor and a negative feedback mediator for renin activity. Thus, it induced decreases in angiotensin II plasma levels, decreases blood pressure. Trandolapril is structurally similar to enalapril and both require hydrolysis for activity. Because of the pharmacokinetics of the active metabolite, itat, it can be administered once daily. Trandolapril is used to treat hypertension (high blood pressure) and heart failure. It can significantly reduce sudden death post-MI, and can decrease progression to severe heart failure, however, it did not reduce the risk of recurrent myocardial infarction.the drug blocks the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor and a negative feedback mediator for renin activity. Thus, it induced decreases in angiotensin II plasma levels, decreases blood pressure and increases plasma renin activity

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Primary Characteristics

It is of Synthetic origin and belongs to Indole.

It belongs to Angiotensin converting enzyme inhibitor-ACEI pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.

Molecular Weight: 430.5 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Trandolapril.

Pharmacokinetics

Distribution: Trandolapril has a plasma protein binding is 80%.

Elimination: it is metabolised via Hepatic, plasma half-life is 16 - 24 hr, renal excretion is 33%.

Indications

Trandolapril is primarily indicated in conditions like Advanced or metastatic breast cancer, Duodenal ulcer associated with h. Pylori, Heart failure, Heart failure (unlicensed indication), Hypertension, Mild to moderate hypertension, Myocardial infarction.

Contraindications

Trandolapril is contraindicated in conditions like Hyperaldoesteronism, Renal artery stenosis, Angioedema.

Dosage

Trandolapril's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2.25 mg	2.25 mg	Every 24h	PO
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended in this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Trandolapril in overdosage may give rise to further complications which include Elevated SGPT & SGOT, Gout , Cardiac stroke, Syncope , AV-block .

Trandolapril is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Bradycardia , Chest pain, Dizziness, Gastritis, Hypotension , Impotence, Increased intracranial pressure, Insomnia, Myalgia, Neutropenia, Pruritus , Rashes , VertigoX, Vomiting .

Warnings / Precautions

Trandolapril should be used with caution in patients with history of angioedema, high blood levels of potassium, kidney dialysis, salt restrictive diet or liver disease. Before using salt substitutes, consult the doctor. Get up slowly, to avoid dizziness and lightheadedness when rising from a seated or lying position. It should be used with caution in patients with pre-existing bone marrow depression. The dose should be adjusted in patients with renal impairment. It should be used cautiously in patients with congestive heart failure. Initial doses should be lower than in the treatment of hypertension becauseof a greater risk of developing hypotension. It should not be administered to patients with pre-existing renal artery stenosis. Renal function should be monitored closely during the first 2 weeks after initiating therapy. It should be discontinued if renal function worsens acutely. It is classified as pregnancy category C and should be used with caution during pregnancy only if clearly needed. It should be used with caution in the elderly patients and in children.

Available Brands

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Single Ingredient

Tabs

0.5 mg 2 mg

Multi-Ingredient Combinations

Tabs

2 mg 4 mg

Storage Conditions

Trandolapril should be stored Tab.

Drug Classification

1.12.3.3 — ACE inhibitors

Manufacturers

Manufacturers of Trandolapril in Pakistan:

Abbott Genix