Topiramate

Drug #1079

Topiramate is a sulphamate-substituted monosaccharide, an antiepileptic agent. Topiramate is structurally different from all other antilepileptic drugs. Topiramate is used as an adjunctive therapy for refaractory partial seizures and primary generalized tonic-clonic seizures. Withdrawal of it therapy or transition to or from another type of antiepileptic therapy should be made gradually to avoid exacerbation of seizures.

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Primary Characteristics

It is of Synthetic origin and belongs to Sulphamate Monosaccharides.

Molecular Weight: 339.4 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Topiramate.

Pharmacokinetics

Distribution: Topiramate has a volume of distribution is 0.7(0.6-0.8)l/kg. plasma protein binding is 13 - 17 %.

Elimination: plasma half-life is 21 hr, renal excretion is ~ 70 %.

Indications

Topiramate is primarily indicated in conditions like Adjunctive treatment of partial seizures, Oedema, Seizures, Seizures associated with lennox gastaut syndrome.

Contraindications

None recorded.

Dosage

Topiramate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
200 mg	200 mg	Every 12h	PO
Paediatric Dosage (20kg)
1.66 mg/kg	1.66 mg/kg	Every 24h	Oral	Initial, at night . Not recommended under 2 yrs. of child
3.5 mg/kg	3.5 mg/kg	Every 12h	Oral	Maintenance.Gradually increase the dose
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown4 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Topiramate is known to cause more or less tolerable side effects which are usually transient. These include Ataxia, Backache , Chest pain, Confusion, Depression, Dizziness, Edema, Hot flushes, Nervousness, Pharyngitis, Rigors , SomnolenceX, Speech problems, Xerostomia .

Warnings / Precautions

Topiramate should be used with caution in patients with any allergy (especially drug allergies), kidney or liver disease. Drink plenty of fluids to decrease the chance of kidney stones. Patient should observe caution while driving or performing other tasks that require mental alertness. It should be used with caution during pregnancy and lactation.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs

100 mg 200 mg 25 mg 50 mg

Storage Conditions

Topiramate should be stored Tab.

Drug Classification

1.5 — Anticonvulsants and Antiepileptics

Manufacturers

Manufacturers of Topiramate in Pakistan: