Tolperisone (HCl)
Tolperisone (HCl) is a centrally acting muscle relaxant. Tolperisone (HCl) is used in the symptomatic treatment of spasticity and muscle spasm.
Primary Characteristics
It is of origin and belongs to Piperidinopropiophenone .
It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action. It is also classified under Gastrointestinal Anticholinergics/Antispasmodics .
Molecular Weight: 281.8 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Tolperisone.
Pharmacokinetics
Distribution: Tolperisone (HCl) has a volume of distribution is . plasma protein binding is .
Elimination: it is metabolised via , plasma half-life is , renal excretion is .
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Indications
Tolperisone (HCl) is primarily indicated in conditions like Muscular hypertension, Obliterative vascular disease.
Contraindications
Tolperisone (HCl) is contraindicated in conditions like Myasthenia gravis.
Dosage
Tolperisone (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 100 mg | 100 mg | Every 12h | IM | |
| 100 mg | 100 mg | Every 24h | IV | |
| 100 mg | 100 mg | Every 8h | PO | |
| Paediatric Dosage (20kg) | ||||
| 1 mg/kg | 1 mg/kg | Every 8h | Oral | Dose for above 6 Yrs of children |
| Neonatal Dosage (3kg) | ||||
| 2.5 mg/kg | 2.5 mg/kg | Every 8h | Oral | |
Drug Interactions
None recorded.
Side Effects
Tolperisone (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Muscle weakness, SomnolenceX.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.20 — Muscle relaxants and cholinesterase inhibitors
Manufacturers
Manufacturers of Tolperisone (HCl) in Pakistan: