Tibolone
Tibolone is a steroid that has oestrogenic, progestogenic, and weak androgenic properties. Tibolone is used as a menopausal hormone replacement therapy in the treatment of menopausal vasomotor symptoms and the prevention of post-menopausal osteoporosis.
Primary Characteristics
It is of origin and belongs to Steroid .
It is classified in Gonadomimetic pharmacological group. It is also classified under Hormones .
Molecular Weight: 312.4 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Tibolone.
Pharmacokinetics
Distribution: Tibolone has a volume of distribution is . plasma protein binding is .
Elimination: it is metabolised via , plasma half-life is , renal excretion is .
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Indications
Tibolone is primarily indicated in conditions like Menopausal symptoms, Osteoporosis, Osteoporosis prophylaxis, Sedation with amnesia.
Contraindications
Tibolone is contraindicated in conditions like Vaginal bleeding, Liver diseases, Thromboembolism, Cardiovascular disease, Cerebrovascular disease.
Dosage
Tibolone's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 2.5 mg | 2.5 mg | Every 24h | PO | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not applicable in paeds | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not applicable in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Tibolone is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Dizziness, Edema, Headache, Migraine , Nausea, Pruritus , Rashes , Weight gain.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.18.4 — Estrogens, their combinations and related preparations