DrugInfoSys

Terbinafine (HCl)

Drug #1053

Terbinafine (HCl) is antifungal agent. Terbinafine (HCl) is a synthetic allylamine and available as oral and topical formulation. Oral terbinafine is highly effective for treating onychomycosis due to its fungicidal activity and ability to concentrate within the nails.

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Primary Characteristics

It is of Synthetic origin.

It is classified in Antifungal Agent, Oral pharmacological group.

Solubility in Water: slightly soluble · Solubility in Alcohol: soluble · Non-proprietary name: Terbinafine (HCl).

Molecular structure of Terbinafine (HCl)

Pharmacokinetics

Absorption: Terbinafine (HCl) has an oral bioavailability is 2.5% (±2.5%).

Distribution: Terbinafine (HCl) has a plasma protein binding is 90%.

Elimination: plasma half-life is 36 hr, renal excretion is 70%.

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Indications

Terbinafine (HCl) is primarily indicated in conditions like Athelets foot, Dermatophyte infections of the nails, Fungal infection, Hair and nail infection, Iron-deficiency anaemia prophylaxis or for mild iron deficiency, Ringworm, Skin infections, Tinea corporis, Tinea cruris, Tinea pedis, Yeast infection.

Contraindications

Terbinafine (HCl) is contraindicated in conditions like Hypersensitivity.

Dosage

Terbinafine (HCl)'s dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
250 mg250 mgEvery 24hPO
1 %1 %Every 12hTopical For 1-2 Weeks
Paediatric Dosage (20kg)
0 – 0——Not recommended in this age group
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions
1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Terbinafine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Increased intracranial pressure, Itching, Nausea, Rashes , Redness, Stinging, Urticaria, Vomiting .

Warnings / Precautions

Terbinafine should be used only if clearly needed during pregnancy. It should be used with caution in patients with any pre-existing illness, infections or allergy, especially to any antibiotic.

Interference in Pathology

Terbinafine (HCl) may interfere in the diagnosis of Abnormal liver enzymes.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Cream
1 %w/w4 %w/w
Lotion
1 %w/v
Spray
1 %w/v
Syrup
1.5 mg/5ml
Tabs
125 mg2.5 mg250 mg

Storage Conditions

Terbinafine (HCl) should be stored Cream. Tab, Cream.

Drug Classification

  1. 1.6.3 — Antifungal drugs
  2. 2.13.1 — Antifungals, topical

Manufacturers