Terazosin
Also known as: Terazosin Hcl
Terazosin is alpha-adrenergic antagonist and a vasodilator, used to treat hypertension. It relaxes and expands blood vessels and lowers the blood pressure. In males, it may also be used to reduce symptoms of urinary obstruction caused by benign prostatic hypertrophy.
Primary Characteristics
Terazosin is also known as Terazosin Hcl.
It belongs to Piperazine.
It belongs to Alpha-1 adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.
Molecular Weight: 459.9 · Solubility in Water: freely soluble · Solubility in Alcohol: null · Non-proprietary name: Terazosin.
Pharmacokinetics
Distribution: Terazosin has a plasma protein binding is 90 - 95 %.
Elimination: plasma half-life is 9.2 - 12 hr, renal excretion is 40 %.
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Indications
Terazosin is primarily indicated in conditions like Benign prostatic hyperplasia, Hypertension, Infertility or irregular cycles, Mild to moderate hypertension.
Contraindications
None recorded.
Dosage
Terazosin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1 mg | 1 mg | Every 24h | PO | Initial dose. To be taken at bed time. |
| 7.5 mg | 7.5 mg | Every 24h | PO | Maintenance |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Terazosin is known to cause more or less tolerable side effects which are usually transient. These include Asthenia , Blurred vision, Chest pain, Dizziness, Drowsiness, Dyspnea, Fatigue, Nasal congestion , Postural hypotension, SomnolenceX.
Warnings / Precautions
Interference in Pathology
Terazosin may interfere in the diagnosis of Hematocrit Value .
Available Brands
Storage Conditions
Drug Classification
- 1.12.3.5 — Alpha-1 receptor antagonists
- 2.29 — Drugs used in renal, bladder, and prostatic disorders