Teicoplanin
Teicoplanin is a glycopeptide antibiotic. Teicoplanin is very similar to Vancomycin in mechanism of action and antibacterial spectrum. Teicoplanin is effective against gram positive bacteria. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Teicoplanin is important to take the drug for the full time period as prescribed. discontinuation of the drug, may result in ineffective treatment.
Primary Characteristics
It is of Semi Synthetic origin and belongs to Glycopeptide.
It belongs to Peptidoglycan transpeptidase inhibitor pharmacological group on the basis of mechanism of action.
Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Teicoplanin.
Pharmacokinetics
Distribution: Teicoplanin has a plasma protein binding is 90 - 95%.
Advertisement
Indications
Teicoplanin is primarily indicated in conditions like Bacillary dysentery, Bacterial infections, Constipation, Constipation and bowel evacuation, Endocarditis, Endocarditis treatment, GI infections, Potentially serious gram +ve infections, Respiratory tract infections, Septicaemia, Serious infections due to staphylococcus aureus, Skin infections, Soft tissue infections, Urinary tract infection.
Contraindications
Teicoplanin is contraindicated in conditions like Epilepsy, Convulsions, Hypersensitivity.
Dosage
Teicoplanin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 200 mg | 200 mg | Every 24h | IV,IM | Maintenance, on each subsequent day of treatment. |
| 400 mg | 400 mg | Every 24h | IV,IM | Initially. |
| Paediatric Dosage (20kg) | ||||
| 8 mg/kg | 8 mg/kg | Every 24h | Intra Muscular | Maintenance |
| 10 mg/kg | 10 mg/kg | Every 8h | Intra Muscular | Loading |
| 8 mg/kg | 8 mg/kg | Every 24h | Intra Venous | Maintenance |
| 10 mg/kg | 10 mg/kg | Every 8h | Intra Venous | Loading |
| Neonatal Dosage (3kg) | ||||
| 8 mg/kg | 8 mg/kg | Every 24h | Intra Muscular | Maintenance |
| 10 mg/kg | 10 mg/kg | Every 8h | Intra Muscular | Loading |
| 8 mg/kg | 8 mg/kg | Every 24h | Intra Venous | Maintenance |
| 10 mg/kg | 10 mg/kg | Every 8h | Intra Venous | Loading |
Drug Interactions
None recorded.
Side Effects
Teicoplanin in overdosage may give rise to further complications which include Bronchospasm , Ototoxicity , Renal failure , Eosinophilia .
Teicoplanin is known to cause more or less tolerable side effects which are usually transient. These include Angioedema, Dizziness, Fever, GI upset, Headache, Hearing loss, Rashes , Reaction at injection site, Rigors , Tinnitus.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.6.2.1.4 — Other inhibitors of cell wall synthesis