Tazobactam (Na)
Tazobactam (Na) is a triazolylmethyl penicillanic acid sulphone. Tazobactam (Na) is a potent inhibitor of many ß lactamase. Tazobactam (Na) is given in combination of piperacillin antibiotic, it enhances and extends the antibiotic spectrum of piperacillin to include many ß lactamase producing bacteria normally resistant to it and other ß lactam antibiotics.
Primary Characteristics
Tazobactam (Na) is also known as Tazobactam.
It is of Synthetic origin and belongs to Penicillanic acid sulphone.
It is classified in Antibacterial pharmacological group.
Molecular Weight: 322.3 · pKa: 2.1 · Solubility in Water: 1 in 2 · Solubility in Alcohol: 1 in 1.1 · Non-proprietary name: Tazobactam (Na).
Pharmacokinetics
Distribution: Tazobactam (Na) has a volume of distribution is 14 litre. plasma protein binding is 23%.
Elimination: plasma half-life is 0.35-0.67 hr.
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Indications
Tazobactam (Na) is primarily indicated in conditions like Intra-abdominal infections, Respiratory tract infections, Septicaemia, Skin infections, Urinary tract infection.
Contraindications
Tazobactam (Na) is contraindicated in conditions like Hypersensitivity.
Dosage
Tazobactam (Na)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 500 mg | 500 mg | Every 8h | Slow IV | In combinaiton with Piperacillin (Na). |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
None recorded.
Side Effects
Tazobactam (Na) produces potentially life-threatening effects which include Pseudomembranous colitis , Anaphylaxis . Careful monitoring is needed with proper medical management.
Tazobactam (Na) is known to cause more or less tolerable side effects which are usually transient. These include Allergic reactions, Diarrhea, Dry mouth, Erythema, Fever, GI disturbance, Hallucination , Hot flushes, Muscle pain, Muscular weakness, Rashes , Reaction at injection site, Tiredness , Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.6.2.1.1 — Penicillins