Simethicone

Also known as: Dimethicone, Activated Dimethicone, Dimethylpolysiloxane, Dimeticone

Drug #1014

Simethicone has anti-foaming and water repellent properties. Simethicone is a mixture of dimethicones and silicon dioxide. Simethicone breaks gas bubbles in the digestive tract. iteffective as an adjunct therapy in condition in which gas is problem to relieve symptoms of excess gas such as air swallowing, dyspepsia, peptic ulcer, post-operative gaseous distention and irritable colon.

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Primary Characteristics

Simethicone is also known as Dimethicone, Activated Dimethicone, Dimethylpolysiloxane, Dimeticone.

It is of Synthetic origin and belongs to Silicondioxide.

It is classified in Antiflatulent pharmacological group. It is also classified under Histamine (H-2) Antagonists .

Molecular Weight: 20500 · Solubility in Water: Insoluble · Solubility in Alcohol: Insoluble · Non-proprietary name: Simethicone.

Pharmacokinetics

None recorded.

Indications

Simethicone is primarily indicated in conditions like Esophagitis, Flatulence, Gastric bloating, Gastrocardiac syndrome, Irritable bowel syndrome, Itchy dermatitis, Meteorism, Oesophagitis, Peptic ulcer, Postoperative gas pains, Skin irritations.

Contraindications

Simethicone is contraindicated in conditions like Allergy, Hypersensitivity to the drug, Hypersensitivity to any component of product.

Dosage

Simethicone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
30 mg	30 mg	Every 6h	PO	After Meals and at bedtime
60 mg	60 mg	Every 6h	PO
Paediatric Dosage (20kg)
0 – 20 mg	—	—	PO	This dose should be taken 4 times a day by children of 2-12 years of age.
Neonatal Dosage (3kg)
No data.

Drug Interactions

2 interactions

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Simethicone in overdosage may give rise to further complications which include Rashes, Hives.

Simethicone is known to cause more or less tolerable side effects which are usually transient. These include Bloating , Burning, Constipation , Diarrhea, Heart burn, Itching, Stinging.

Warnings / Precautions

Simethicone should be used with caution in patients with any pre-existing illness or allergy. It should be used only if clearly needed during pregnancy or lactation. Tell your health care provider if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding. If you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement. If you have allergies to medicines, foods, or other substances. If you have an open wound, serious burn, or damaged, broken, or irritated skin. Do not get Dimethicone Cream in your eyes, nose, or mouth. If you get Dimethicone Cream in your eyes, rinse immediately with cool tap water. Wash your hands before and after using Dimethicone Cream unless your hands are a part of the treated area.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Drops

40 mg/ml

Susp

25 mg/5ml

Susp

40 mg/5ml

Multi-Ingredient Combinations

Caps

Drops

Gel

Liquid

Susp

125 mg/5ml 25 mg/5ml 30 mg/5ml

Susp

20 mg/5ml 50 mg/5ml

Syrup

25 mg/5ml

Tabs

20 mg 25 mg 30 mg 40 mg 50 mg

Storage Conditions

Simethicone should be stored Drops. Tab, Caps.

Drug Classification

1.17.1.1 — Antacids & antiflatulents
2.17.10 — Antiobesity preparations

Manufacturers

Manufacturers of Simethicone in Pakistan: