Sertraline (HCl)
Sertraline (HCl) is oral antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) type. Sertraline (HCl) is similar to fluoxetine and paroxetine. Sertralin has one active metabolite and the lowest potential for drug interactions involving CYP2D6 (cytochrome P-450 isoenzyme 2D6) of the SSRIs. Sertraline has also been used in the treatment of obsessive-compulsive disorder (OCD). Sertraline was approved by the FDA in December 1991 for the treatment of major depression. In October 1996, it was approved for treatment of OCD. Sertraline (HCl) is believed that sertraline and related agents inhibit reuptake of serotonin at the neuronal membrane, and potentiate serotonin (5-HT) in the CNS.
Primary Characteristics
Sertraline (HCl) is also known as Sertraline.
It is of Synthetic origin and belongs to Naphthalene Amine.
It is classified in Antidepressant pharmacological group. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 342.7 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Sertraline (HCl).
Pharmacokinetics
Distribution: Sertraline (HCl) has a plasma protein binding is high.
Elimination: plasma half-life is 24 hr, renal excretion is <1%.
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Indications
Sertraline (HCl) is primarily indicated in conditions like Depression, Depressive illness, Obsessive-compulsive disorders, Panic attack, Post traumatic stress disorder.
Contraindications
None recorded.
Dosage
Sertraline (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 50 mg | 50 mg | Every 24h | PO | Initially for 2 Weeks |
| 125 mg | 125 mg | Every 24h | PO | Maintenance for 1 Month |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Safety not established | |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Sertraline (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Dizziness, Ejaculatory disturbances, Fatigue, Headache, Insomnia, Nausea, Palpitation, SomnolenceX, Xerostomia .
Warnings / Precautions
Interference in Pathology
Sertraline (HCl) may interfere in the diagnosis of Elevations of SGPT and SGOT , Elevation in ALT or AST, Increased serum triglycerides.
Available Brands
Storage Conditions
Drug Classification
- 1.24.2.1 — Drugs used in depression