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Selegiline (HCl)

Drug #1007

Selegiline (HCl) is a selective inhibitor of monoamine oxidase B. Selegiline (HCl) is used along with levodopa in the management of Parkinson's disease. It inhibits the breakdown of dopamine in the brain and prolongs the action of Levodopa

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Primary Characteristics

It is of Synthetic origin and belongs to Phenethylamine.

It is classified in Antiparkinson Agents pharmacological group.

Molecular Weight: 223.7 · pKa: 6.88 · Solubility in Water: 1 in 3 · Solubility in Alcohol: 1 in 3 · Non-proprietary name: Selegiline (HCl).

Molecular structure of Selegiline (HCl)

Pharmacokinetics

Absorption: Selegiline (HCl) has an oral bioavailability is 100%.

Distribution: Selegiline (HCl) has a volume of distribution is 4.7 l/kg. plasma protein binding is 94 %.

Elimination: plasma half-life is 9 min, renal excretion is 75 %.

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Indications

Selegiline (HCl) is primarily indicated in conditions like Parkinsonism, Parkinson's disease, Parkinson's disease or symptomatic parkinsonism.

Contraindications

Selegiline (HCl) is contraindicated in conditions like Psychosis, Extrapyramidal disorders, Tardive dyskinesias, Huntington's disease.

Dosage

Selegiline (HCl)'s dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
7.5 mg7.5 mgEvery 24hPO
Paediatric Dosage (20kg)
0 – 0——Not applicable in paeds
Neonatal Dosage (3kg)
0 – 0——Not applicable in this age group

Drug Interactions

Unknown6 interactions
8 interactions
Major6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Selegiline (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anemia, Confusion, Diarrhea, Dizziness, Dyskinesia , Malaise, Nausea, Palpitation, Urinary retention, Weight loss.

Warnings / Precautions

Selegiline should be used with caution in patients with peptic ulcer and of allergies, especially of drug allergies. Rarely, this can cause headache and increased blood pressure when tyramine containing foods are ingested, consult the doctor about the use of diet containing tyramine (e.g.meat, fish, pickle, liver, dry sausage, meat prepared with tenderizer, yogurt, cheese, beverages, cheery, excessive amounts of caffeine, bananas, figs, raisins, broad beans, soy sauce, chocolate). Caution regarding food should be continued at least 2 weeks after discontinuing use of this drug. This drug should be used during pregnancy only if clearly needed.

Available Brands

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Single Ingredient

Tabs
5 mg

Storage Conditions

Selegiline (HCl) should be stored Tab.

Drug Classification

  1. 1.9.1 — Drugs used in parkinsonism

Manufacturers

Manufacturers of Selegiline (HCl) in Pakistan:

Al-HabibAventisEvronGenomeGSK