Roxithromycin

Drug #1001

Roxithromycin is a macrolide with antibacterial properties similar to that of Erythromycin. Roxithromycin is active against gram positive bacteria for example, staphylococci, streptococci, listeria, corynebacteria; gram negative bacteria for example gonococci, Hemophilus influenza, Hemophilus ducreyi, Legionella, and atypical pathogen, for example mycoplasma and chlamydia. Roxithromycin is well torelated by children and adults. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular interval of time throughout the day and night as prescribed. Roxithromycin is important to take the drug for the full time period as prescribed, discontinuation of the drug may result in ineffective treatment.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Methyloxime.

It is classified in Macrolide pharmacological group.

Molecular Weight: 837 · Solubility in Water: very slightly soluble · Solubility in Alcohol: freely soluble · Non-proprietary name: Roxithromycin.

Pharmacokinetics

Absorption: Roxithromycin has an oral bioavailability is 25% (±25%).

Distribution: Roxithromycin has a plasma protein binding is 96%.

Elimination: plasma half-life is 9-16 hr, renal excretion is 7-12%.

Indications

Roxithromycin is primarily indicated in conditions like Ent infections, Genitourinary tract infections, Pneumonia, Skin infections.

Contraindications

Roxithromycin is contraindicated in conditions like Hepatic disease, Hypersensitivity.

Dosage

Roxithromycin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
150 mg	150 mg	Every 12h	PO	Take before meal.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Roxithromycin is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Dizziness, Elevated alkaline phosphatase, Elevated SGPT & SGOT, Epigastric pain, GI disturbance, Headache, Nausea and vomiting, Rashes , Weakness.

Warnings / Precautions

Precaution should be taken in hepatic insufficiency, prenancy and lactation. It should be used with caution in patients with any allergy, especially to antibiotics. Take appropriate measures if secondary infection occurs.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps

150 mg 300 mg

Susp

50 mg/5ml

Tabs

100 mg 150 mg 300 mg 50 mg

Storage Conditions

Roxithromycin should be stored .

Drug Classification

1.6.2.2.4 — Macrolides

Manufacturers

Manufacturers of Roxithromycin in Pakistan: