Hemolytic-uremic syndrome

HUS is defined as the combination of a microangiopathic hemolytic anemia with variable degrees of thrombocytopenia and renal failure. The syndrome usually occurs in previously healthy children and often is preceded by a gastrointestinal enteritis. Other systems may be involved, such as the central nervous system (CNS). When fever and CNS manifestations coexist, the distinction between HUS and thrombotic thrombocytopenic purpura (TTP) can be difficult.