DrugInfoSys

Quetiapine

Drug #989

Quetiapine is antipsychotic drug. Quetiapine is used to treat mental disorders such as schizophrenia.

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Primary Characteristics

Quetiapine is also known as Quetiapine Fumarate.

It belongs to Dibenzothiazepine.

It is classified in Antipsychotic Agent pharmacological group. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 883.1 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Quetiapine.

Molecular structure of Quetiapine

Pharmacokinetics

Distribution: Quetiapine has a plasma protein binding is 83 %.

Elimination: it is metabolised via Hepatic, plasma half-life is ~ 6 hr, renal excretion is 73 %.

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Indications

Quetiapine is primarily indicated in conditions like Mania, Psychosis, Schizophrenia.

Contraindications

Quetiapine is contraindicated in conditions like Blood dyscrasias, Bone marrow depression, Coma, CNS depression.

Dosage

Quetiapine's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
25 mg25 mgEvery 12hPOInitially.Then 50 mg BID on day 2, 100 mg BID on day 3 then adjust to a usual range of 300-450 mg/day.
Paediatric Dosage (20kg)
0 – 0——Not recommended in this age group
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown7 interactions
1 interaction
Major1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Quetiapine in overdosage may give rise to further complications which include Neuroleptic malignant syndrome , Tachycardia , Neutropenia , Transient leucopenia .

Quetiapine is known to cause more or less tolerable side effects which are usually transient. These include Constipation , Dizziness, Dry mouth, Liver enzyme abnormalities, Orthostatic hypotension, SomnolenceX.

Warnings / Precautions

Quetiapine should be used with caution in patients with any allergy (especially drug allergies), liver or heart disease, blood vessel disease, very low blood pressure, seizure disorder or brain cancer. Get up slowly, to avoid dizziness and lightheadedness when rising from a seated or lying position. Limit alcohol intake as it may aggravate side effects. Caution is advised when performing activities requiring mental alertness (e.g.driving). This drug might hinder body temperature control, it is advised not to exercise strenuously and to avoid extreme heat while using this. It should be used only when clearly needed during pregnancy. Avoid use during lactation. Caution when this drug is used in the elderly.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs
100 mg150 mg200 mg25 mg300 mg400 mg

Storage Conditions

Quetiapine should be stored Tab.

Drug Classification

  1. 1.24.1 — Drugs used in psychotic disorders

Manufacturers