Pyrilamine (Maleate)

Drug #987

Pyrilamine (Maleate) is anti-histamine, used in treatment of allergic rhinitis and allergic conjunctivitis and for prevention of allergic reactions to blood or plasma in patients with a known history of such reactions.

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Primary Characteristics

It belongs to Ethylenediamine.

It belongs to H1-antagonist pharmacological group on the basis of mechanism of action and also classified in Anti Allergic Agent pharmacological group.

Molecular Weight: 401.5 · Solubility in Water: 1 in 0.5 · Solubility in Alcohol: 1 in 3 · Non-proprietary name: Pyrilamine Maleate · pH: 4.9.

Molecular structure of Pyrilamine (Maleate)

Pharmacokinetics

None recorded.

Indications

Pyrilamine (Maleate) is primarily indicated in conditions like Cold, Cough, Hypersensitivity reactions, Pruritus.

Contraindications

None recorded.

Dosage

Pyrilamine (Maleate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.1 %	0.1 %	Every 4h	Ophthalmic	As required.
37.5 mg	37.5 mg	Every 4h	PO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Pyrilamine (Maleate) produces potentially life-threatening effects which include Bone marrow suppression. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Pyrilamine (Maleate) are Coma, Unconsciousness, Convulsions , Hypertension.

Pyrilamine (Maleate) is known to cause more or less tolerable side effects which are usually transient. These include Drowsiness, Paresthesias.

Warnings / Precautions

Pyrilamine should be used with caution in bone marrow depression. Patients should observe caution while driving or performing other task requiring alertness because it may cause drowsiness. It should be used with caution in patients with urinary retention, history of bronchial asthma, hyperthyroidism, cardiovascular or liver disease. It should be used with caution in person with acute or chronic respiratory impairment, especially in children. Do not give S/C because irritation or lesion may occur.

Available Brands

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Multi-Ingredient Combinations

Eye Drops

0.1 %v/v 0.1 %w/v

Syrup

15 mg/5ml

Storage Conditions

Pyrilamine (Maleate) should be stored Tab, Caps, Susp, Liq.

Drug Classification

1.21.6 — Non-specific anticonjunctivitis preparations
2.25.2.1 — Cold preparations

Manufacturers

Manufacturers of Pyrilamine (Maleate) in Pakistan:

Barrett Jaens Pfizer Remington