Phytomenadione
Phytomenadione or vitamin K1, is a synthetic compound that is chemically indistinguishable from naturally occurring vitamin K1. Vitamin K is found in both plant and animal sources, and is also produced by intestinal bacteria; however, vitamin K from these different sources is not identical. Phytonadione is found in plants and is the only natural vitamin K available for therapeutic use. Menaquinones (vitamin K 2) are a series of compounds that can be synthesized by bacteria. Vitamine K is an essential cofactor in the hepatic synthesis of prothrombin and other blood clotting factors. vitamin K decreases the effects of oral anticoaggulants, and is used to counteract excessive effects of these drugs.
Primary Characteristics
It belongs to Naphthalene.
It is classified in Vitamin K Derivative pharmacological group.
Molecular Weight: 450.7 · Solubility in Water: Insoluble · Solubility in Alcohol: sparingly · Non-proprietary name: Phytomenadione.
Pharmacokinetics
None recorded.
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Indications
Phytomenadione is primarily indicated in conditions like Haemorrhage, Haemorrhagic disease of newborn, Hypoprothrombinemia.
Contraindications
Phytomenadione is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
Phytomenadione's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 11.25 mg | 11.25 mg | — | IV,IM,SC | As Required |
| 15 mg | 15 mg | — | PO | As Required |
| Paediatric Dosage (20kg) | ||||
| 0.3 mg/kg | 0.3 mg/kg | — | Intra Muscular | Single Dose |
| 0.3 mg/kg | 0.3 mg/kg | — | Oral | Single Dose |
| 0.3 mg/kg | 0.3 mg/kg | — | slow Intra venous | Single Dose |
| Neonatal Dosage (3kg) | ||||
| 0.3 mg/kg | 0.3 mg/kg | — | Intra Muscular | Single Dose |
| 0.3 mg/kg | 0.3 mg/kg | — | Oral | Single Dose |
| 0.3 mg/kg | 0.3 mg/kg | — | slow Intra venous | Single Dose |
Drug Interactions
None recorded.
Side Effects
The signs and symptoms that are produced after acute overdosage of Phytomenadione are Hyperbilirubinemia, Jaundice , Hemolytic anemia.
Phytomenadione is known to cause more or less tolerable side effects which are usually transient. These include Cyanosis, Flushing, SweatingX.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.10.3 — Antihemorrhagics/Antihemophilics
- 2.27 — Vitamins, minerals, tonics, and other susbstances