Pantoprazole

Drug #952

Pantoprazole is a proton pump inhibitor and causes long lasting inhibition of gastric acid secretion and used in the treatment of peptic ulcers. Chemically Pantoprazole is identified as 5-(difluoromethoxy)-2-[[(3,4-dimethyl-2-pyridinyl) methyl] sulfinyl]-1H-benzimidazole. Pantoprazole is a novel substituted benzimidazole sulfoxide derived prodrug similar to omeprazol and lansoprazol. Pantoprazole is administered orally.

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Primary Characteristics

Pantoprazole is also known as Pantoprazole (sodium sesquihydrate), Pantoprazole Sodium.

It is of Synthetic origin and belongs to Benzimidazole.

It belongs to H/K Atpase proton pump inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Antacids .

Molecular Weight: 383.4 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Pantoprazole.

Pharmacokinetics

Distribution: Pantoprazole has a volume of distribution is 17.5 litre. plasma protein binding is 98%.

Elimination: plasma half-life is 1 hr, renal excretion is 71%.

Indications

Pantoprazole is primarily indicated in conditions like Benign gastric ulcer, Duodenal ulcer, Duodenal ulcer and gastric ulcer, Duodenal ulcer associated with h. Pylori, Esophagitis, Gastro-oesophageal reflux disease, Oesophagitis, Peptic ulcer, Prophylaxis of NSAID-associated gastric or duodenal ulcer, Zollinger-ellison syndrome.

Pantoprazole is also indicated for secondary conditions like Prophylaxis of NSAID-associated gastric or duodenal ulcer.

Contraindications

Pantoprazole is contraindicated in conditions like Hypersensitivity.

Dosage

Pantoprazole's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.571 mg/kg	0.571 mg/kg	Every 24h	PO	For 8 weeks
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended for this age group
Neonatal Dosage (3kg)
No data.

Drug Interactions

9 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Pantoprazole is known to cause more or less tolerable side effects which are usually transient. These include Anxiety, Arthralgia, Backache , Bronchitis , Chest pain, Cough , Dizziness, Dyspnea, Flu like syndrome, Hyperglycemia, Hyperlipidemia, Hypertonia, Migraine , Nausea, Neck pain, Pain , Pharyngitis, Rectal disorders, Rhinitis , Sinusitis , Urinary frequency, UTI , Vomiting , Weakness.

Warnings / Precautions

Pantoprazole should be used with caution in patients with liver or kidney disease or of any drug allergy. It should be used only when clearly needed during pregnancy. Avoid use during lactation. The elderly may be especially sensitive to this drug, so use with caution.

Interference in Pathology

Pantoprazole may interfere in the diagnosis of Liver Function Tests .

Available Brands

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Single Ingredient

Caps

Inf

Inj

Tabs

Vag Tabs

Multi-Ingredient Combinations

Tabs

40 mg

Storage Conditions

Pantoprazole should be stored .

Drug Classification

1.17.1.2 — Anti-peptic ulcerants