Mesterolone

Drug #923

Mesterolone is a sex hormone with actions and uses similar to Testosterone. Mesterolone is used to treat some menstrual disorders, in breast cancer and for suppression of lactation.

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Primary Characteristics

It belongs to Steroid.

It is also classified under Sex Hormones .

Molecular Weight: 304.5 · Solubility in Water: Practically insoluble · Solubility in Alcohol: null · Non-proprietary name: Mesterolone.

Pharmacokinetics

Absorption: Mesterolone has an oral bioavailability is 1.5% (±1.5%).

Elimination: plasma half-life is 12-13hr, renal excretion is 77% metabolise.

Indications

Mesterolone is primarily indicated in conditions like Androgen deficiency and male infertility, Disorders due to androgen deficiency, Hypogonadism, Infertility.

Contraindications

Mesterolone is contraindicated in conditions like Prostatic cancer, Hepatic carcinoma.

Dosage

Mesterolone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
62.5 mg	62.5 mg	—	PO	Daily in divided doses. For maintanance.
87.5 mg	87.5 mg	Every 8h	PO	Initiation therapy for several months.
Paediatric Dosage (20kg)
0 – 0	—	—		Not applicable in this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not applicable in this age group

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Mesterolone produces potentially life-threatening effects which include Liver tumors. Careful monitoring is needed with proper medical management.

Mesterolone is known to cause more or less tolerable side effects which are usually transient. These include Erectile disturbance, Frequent & persistent erection, Hepatic tumors.

Warnings / Precautions

Mesterolone should be used with caution in patients with any disease, especially cancer of the prostate or breast, liver, heart, kidney disease, allergy, enlarged prostate. High dosage, long term use of androgens has been related to liver cancer. This drug should not be used during pregnancy or lactation. Females should be monitored for signs of virilization, such as deepening of the voice, facial hair, acne, menstrual irregularity or clitoral enlargement, consult the doctor promptly if any of these symptoms occurs. Use in children should not be recommended due to the possibility this drug may have undesirable effects related to the growth of the child. It should be used with extreme caution in geriatric (men) because they are at higher risk for developing enlarged prostates or prostate cancer when using this medication.

Available Brands

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Single Ingredient

Tabs

25 mg

Storage Conditions

Mesterolone should be stored Tab.

Drug Classification

1.18.2 — Androgens

Manufacturers

Manufacturers of Mesterolone in Pakistan:

Bayer Global Hansel