Loxoprofen (Sodium)
Loxoprofen (Sodium) is NSAID (non-steroidal antinflammatory drug) and a prodrug of a propionic acid derivative. It has antinflammatory and antipyretic properties. Loxoprofen (Sodium) is optically active and marketed as racemic mixture. Loxoprofen (Sodium) is not available in any combination preparations. Loxoprofen (Sodium) is administered orally.
Primary Characteristics
It is of Synthetic origin and belongs to Propionic acid.
It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 304.3 · pKa: 4.2 · Solubility in Water: freely soluble · Solubility in Alcohol: soluble · Non-proprietary name: Loxoprofen (Sodium).
Pharmacokinetics
Distribution: Loxoprofen (Sodium) has a volume of distribution is 7.6 litre. plasma protein binding is 97.7%.
Elimination: it is metabolised via Hepatic glucuvonidation, plasma half-life is 75 mins, renal excretion is 50%.
Advertisement
Indications
Loxoprofen (Sodium) is primarily indicated in conditions like Cervical spondylosis, Lumbago, Osteoarthritis, Pain, Periarthritis, Rheumatoid arthritis, Toothache.
Contraindications
Loxoprofen (Sodium) is contraindicated in conditions like Peptic ulcer, Haematological disorders, Hypersensitivity.
Dosage
Loxoprofen (Sodium)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 90 mg | 90 mg | Every 8h | PO | As Required |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended for this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
None recorded.
Side Effects
Loxoprofen (Sodium) in overdosage may give rise to further complications which include Anemia , Anemia , Hypersensitivity reactions , Anemia, Leukemia, Eosinophilia .
Loxoprofen (Sodium) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Heart burn, Increased intracranial pressure, Indigestion , Itching, Rashes , StomatitisX, Urticaria.
Warnings / Precautions
Interference in Pathology
Loxoprofen (Sodium) may interfere in the diagnosis of Increased Alkaline Phosphatase Levels, Elevations of GOTand GPT.
Available Brands
Storage Conditions
Drug Classification
- 1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)