Betahistine (HCl)
Betahistine (HCl) is a histamine analogue used as a vasodialtor to reduce the frequency of attacks of dizziness in Menier'e disease, administered orally.
Primary Characteristics
It is of Synthetic origin and belongs to Amino Pyridine.
It belongs to Histamine agonist pharmacological group on the basis of mechanism of action and also classified in H3 Antagonist pharmacological group.
Molecular Weight: 209.1 · pKa: 3.5 · Solubility in Water: > 1 in 10 · Solubility in Alcohol: > 1 in 30 · Non-proprietary name: Betahistine (HCl).
Pharmacokinetics
Absorption: Betahistine (HCl) has an oral bioavailability is 100%.
Distribution: Betahistine (HCl) has a plasma protein binding is 0-5%.
Elimination: it is metabolised via via Liver, plasma half-life is 3.5 hr, renal excretion is 85-90%.
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Indications
Betahistine (HCl) is primarily indicated in conditions like Hearing loss, Menieres disease, Tinnitus, Vertigo.
Contraindications
Betahistine (HCl) is contraindicated in conditions like Asthma, Peptic ulcer, Phaeochromocytoma, Rhinitis, Urticaria.
Dosage
Betahistine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 16 mg | 16 mg | Every 8h | PO | Initial, increase dose as per response |
| 36 mg | 36 mg | Every 24h | PO | Maintenance. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
The signs and symptoms that are produced after acute overdosage of Betahistine (HCl) are Vomiting, Nausea, Dyspepsia, Ataxia, Seizures.
Betahistine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Drowsiness, Dyspepsia , Headache, Nausea.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis