Diphtheria Antitoxin

Drug #888

Diphtheria Antitoxin is a sterile preparation containing the specific antitoxic globulins that have the power of neutralising the toxin formed by Corynebacterium diphtheriae. Diphtheria Antitoxin is used for passive immunization in suspected cases of diphtheria.

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Primary Characteristics

Diphtheria Antitoxin is also known as Immuno serum diphthericum.

It is of origin and belongs to Proteins .

It is also classified under Antitoxins and Antivenins .

Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Diphtheria Antitoxin.

Molecular structure of Diphtheria Antitoxin

Pharmacokinetics

Distribution: Diphtheria Antitoxin has a volume of distribution is . plasma protein binding is .

Elimination: it is metabolised via , plasma half-life is , renal excretion is .

Indications

Diphtheria Antitoxin is primarily indicated in conditions like Diphtheria.

Contraindications

Diphtheria Antitoxin is contraindicated in conditions like Asthma, Hypersensitivity to the drug.

Dosage

Diphtheria Antitoxin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
70000 IU	70000 IU	—	IM,IV Inf	As Required
Paediatric Dosage (20kg)
20000 IU	20000 IU	—	Intra Muscular	Once or as Required
20000 IU	20000 IU	—	Intra Venous	Once or as Required
Neonatal Dosage (3kg)
20000 IU	20000 IU	—	Intra Muscular	Once or as Required
20000 IU	20000 IU	—	Intra Venous	Once or as Required

Drug Interactions

None recorded.

Side Effects

Diphtheria Antitoxin is known to cause more or less tolerable side effects which are usually transient. These include Fever, Itching, Muscle aching, Swelling of face, Swelling of feet, Tiredness .

Warnings / Precautions

Before injecting, information should be obtained whenever possible, as to whether previous injection have been received and whether the patient is subject to hypersensitivity disorders. Sensitivity testing should be performed before administration of antitoxin. The patient must be kept under observation after the administration of full dose. Adrenaline injection and resuscitation facilities should be available.It has a potency of not less than 1000 international units per ml when obtained from horse serum and not less than 500 international units /ml when obtained from otha mammals.

Available Brands

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Single Ingredient

Inj

10000 IU/ml

Storage Conditions

Diphtheria Antitoxin should be stored IV Inj, IM Inj.

Drug Classification

1.19.2.3 — Diphtheria antitoxin

Manufacturers

Manufacturers of Diphtheria Antitoxin in Pakistan:

Hakimsons