Dimenhydrinate
Also known as: Diphenhydramine (Theoclate)
Dimenhydrinate is a H1 antihistaminic or antiemetic agent. It provides relief of symptoms of allergic reactions such as rash, hives, watery eyes, runny nose, itchy eyes and sneezing. It may also be used to treat motion sickness, relief of anxiety or tension and sleeplessness. Administered orally.
Primary Characteristics
Dimenhydrinate is also known as Diphenhydramine (Theoclate), Dimenhydrinate HCL.
It is of Synthetic origin and belongs to Ethanolamine.
It belongs to H1-antagonist pharmacological group on the basis of mechanism of action and also classified in Sedative Anthihistamine pharmacological group. It is also classified under Antiemetic/Antivertigo Agents .
Molecular Weight: 470 · Solubility in Water: 1 in 95 · Solubility in Alcohol: 1 in 2 · Non-proprietary name: Dimenhydrinate.
Pharmacokinetics
Absorption: Dimenhydrinate has an oral bioavailability is 93% (±3%), pre-systemic (first-pass) metabolism accounts for 25% (±25%).
Distribution: Dimenhydrinate has a volume of distribution is 3.28 l/kg. plasma protein binding is 85-98%.
Elimination: plasma half-life is 2.4-8 hr.
Advertisement
Indications
Dimenhydrinate is primarily indicated in conditions like Dizziness, Menieres disease, Motion sickness, Nausea and vomiting, Vertigo, Vestibular disorders.
Contraindications
Dimenhydrinate is contraindicated in conditions like Hypersensitivity to the drug, Hypersensitivity to any component of product.
Dosage
Dimenhydrinate's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 50 mg | 50 mg | — | IV or IM | Usaully over 2 minutes. |
| 75 mg | 75 mg | Every 6h | PO,IV,IM | |
| Paediatric Dosage (20kg) | ||||
| 25 – 50 mg | — | — | To maximum of 15 mg daily. ( 6 to 12 years) | |
| 1.25 mg/kg | 1.25 mg/kg | Every 6h | Intramuscular | Not recommended below 2 years children |
| 1.25 mg/kg | 1.25 mg/kg | Every 6h | Intravenous | Not recommended below 2 Yrs children |
| 12.5 – 125 mg/kg | — | Every 6h | Oral | To maximum of 75mg daily.(2-up to 6 year) and 6 to 8 hourly |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended below 2 yrs. of children | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
The signs and symptoms that are produced after acute overdosage of Dimenhydrinate are Convulsions , Drowsiness, Drowsiness.
Dimenhydrinate is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Arthralgia, Diarrhea, dizziness, Drowsiness, Fatigue, Headache, Increased appetite, Nausea, nervousness, Pharyngitis, Weight gain, Xerostomia .
Warnings / Precautions
Available Brands
Click on a strength to view available brands.
Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.17.2 — Antiemetics & antinauseants