Diclofenac (K)

Drug #877

Diclofenac (K) is NSAID (non-steroidal anti-inflammatory drug). Diclofenac (K) is a simple phenylacetic acid derivative. It resembles both flurbiprofen and meclofenamate. It reduces fever and inflammation and relieves pain.

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Primary Characteristics

It is of Synthetic origin and belongs to Phenylacetic Acid.

It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 334.2 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Diclofenac (K).

Pharmacokinetics

Distribution: Diclofenac (K) has a plasma protein binding is 99%.

Elimination: plasma half-life is 1-2 hr, renal excretion is 65%.

Indications

Diclofenac (K) is primarily indicated in conditions like Adnexitis, Dysmenorrhoea, Inflammation, Migraine, Post-operative pain, Post-traumatic pain, Rheumatoid arthritis.

Contraindications

Diclofenac (K) is contraindicated in conditions like GI ulceration, Hypersensitivity.

Dosage

Diclofenac (K)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
50 mg	50 mg	Every 8h	PO	Additional dose of 50mg MA X BE taken after 2 hour if syptoms persest maximum daily dose 200mg.
Paediatric Dosage (20kg)
0.416 mg/kg	0.416 mg/kg	Every 8h	Oral
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown5 interactions

4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Diclofenac (K) is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Elevation of liver enzymes, Erythema multiforme, GI hemorrhage, GI upset, Headache, Rashes , Vertigo, Vision disturbances.

Warnings / Precautions

Diclofenac potassium should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, asthma, hypertension and other conditions predisposing to fluid retention. It should be used with extra care in the presence of existing uncontrolled infection. Perform periodic auditory (hearing) function test during chronic therapy. Discontinue drug if skin reaction occurs.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps

Caps SR

Gel

Inj

Tabs

100 mg 20 mg 25 mg 50 mg 75 mg

Tabs SR

100 mg

Multi-Ingredient Combinations

Tabs

50 mg

Storage Conditions

Diclofenac (K) should be stored Inj, Tab, Eye Drops.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)
2.2.5 — Antirheumatics, topical

Manufacturers

Manufacturers of Diclofenac (K) in Pakistan:

Akson Albro Alfalah Pharma Alkemy Alliance Alson Ambrosia Amros Anchor Aries Asian Axis Barrett Basel Batala Benson Bio Pharma Biogen Biogenics Biorex Bloom Bosch Candid Caraway Caylex CCL Cherwel Cibex Crest Crown Danas Davis Delta Delux Dr.Raza E Pharm English Envoy Epla Everest Evergreen Fassgen Ferroza Flow Fozan Friends Fynk Genera Genome Glitz Global Goodman Gray's Hamaz Hansel Harmann Healer High-Q Hilton Hiranis Honig Hygeia Ideal Irza Jawa Jinnah KCI Lexicon Lloyds Lotus Lowitt Macquins Makson Max Medera Mediceena Medicraft MEDISAVE Meditech Medizan Lab Miracle Nabiqasim Navegal Nawan Labs Nenza Neo Neutro Nimrall Noa Hemis Novamed Novartis Obsons Ocean Olive Olive Labs Orta Pakheim Paramount PDH Pearl Pharmawise Platinum Polyfine PPP Qintar Qureshi Rakaposhi Rasco Regent Reko Robins Rogen Roryan Pharma Rotex Saaaf Sami Sapient Saydon Sayyad Searle Selmore Shaheen Pharma Shawan Shazal Shrooq Silver Siza Standard Star Swan Swiss Pharma Syntex Tabros Tagma TFC PHARMA Unexo Unimark Unipharma Unison Universal Usawa Valor Vega Venture Venus Vision Webrose Well Wellborne Welmark Wilshire Wise WnsFeild Z-Jans Zafa Zanctok Zeb Zephyr Zesion Zinta