Dalteparin

Drug #873

Dalteparin is a newer anticoagulant agent. Dalteparin is a heparin fraction. its molecular weight range is 2000-9000. Dalteparin is also used in the treatment of unstable angina.

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Primary Characteristics

Dalteparin is also known as Dalteparin sodium.

It is of Natural origin and belongs to Heparin.

It is classified in Low Molecular Weight Heparin pharmacological group.

Molecular Weight: 2000 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Dalteparin.

Pharmacokinetics

Absorption: Dalteparin has an oral bioavailability is 43.5% (±43.5%).

Distribution: Dalteparin has a volume of distribution is 40 - 60 ml/kg.

Elimination: plasma half-life is 3-5 hr after s/c injection 2 hr after IV inj.

Indications

Dalteparin is primarily indicated in conditions like Angina pectoris, Deep vein thrombosis, Myocardial infarction prophylaxis, Obesity, Pulmonary embolism, Unstable angina.

Contraindications

Dalteparin is contraindicated in conditions like Thrombocytopenia, Hypersensitivity to the drug.

Dosage

Dalteparin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
120 IU/ kg	120 IU/ kg	Every 12h	SC	Max. 1000IU/24hrs. Treatment period is 5-8 days concomitant therapy with low dose aspirin is recommended
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Dalteparin in overdosage may give rise to further complications which include Thrombocytopenia , Anaphylactic reactions .

The signs and symptoms that are produced after acute overdosage of Dalteparin are Easy brusing, Easy brusing, Black,tarry stools..

Dalteparin is known to cause more or less tolerable side effects which are usually transient. These include Bleeding , Bullous rash, Fever, Pruritus , Reaction at injection site.

Warnings / Precautions

Dalteparin should be used with caution in patients with medical history, especially have any bleeding disorders, ulcers, liver disease, kidney disease, high blood pressure, heart disease, history of stroke or allergies, especially to heparin. This medication is classified as pregnancy category B and should be used only if clearly needed during pregnancy or lactation.

Interference in Pathology

Dalteparin may interfere in the diagnosis of Elevations of SGPT and SGOT , Elevation in ALT or AST.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj

10000 IU/ml 7500 IU/0.3ml

Inj

5000 IU/ml

Storage Conditions

Dalteparin should be stored Inj.

Drug Classification

1.10.2 — Anticoagulants/Platelet deaggregators

Manufacturers

Manufacturers of Dalteparin in Pakistan:

Pfizer