Carbachol

Drug #835

Carbachol is a muscarinic and nicotinic agonist. It has a carbamic acid etser link which is not readily susceptible to hydrolysis by cholinesterases. It has all the pharmacologic properties of acetylcholine. Carbachol is used to reduce intraocular pressure in the treatment of glaucoma.

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Primary Characteristics

It is of Synthetic origin and belongs to Carbamoyl Choline.

It is classified in Antiglaucoma pharmacological group. It is also classified under Opthalmic Products .

Molecular Weight: 182.6 · Solubility in Water: 1g/ml · Solubility in Alcohol: null · Non-proprietary name: Carbachol · pH: 5.9 · Isotonic value: 2.82.

Pharmacokinetics

None recorded.

Indications

Carbachol is primarily indicated in conditions like Glucoma, Miosis induction, Ocular hypertension.

Contraindications

Carbachol is contraindicated in conditions like Inflammation, Iritis, Corneal abrasion.

Dosage

Carbachol's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.01 %	0.01 %	—	Intra Occular	As required
0.05 mg	0.05 mg	—	Ophthalmic	As Required
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Carbachol in overdosage may give rise to further complications which include Hypotension , Bradycardia , Explosive defecation, Hypothermia , Profuse sweating .

Carbachol is known to cause more or less tolerable side effects which are usually transient. These include Asthma, Blurred vision, Bullous keratopathy, Burning, Ciliary spasm, Corneal clouding, Decrease in visual acuity, Diarrhea, Eye Pain , Headache, Intestinal cramps, Stinging, Stomachache , Transient fall in BP.

Warnings / Precautions

Carbachol should be used with caution in patients with eye problems, asthma, intestinal disease, ulcers, low or high blood pressure, heart disease, hyperthyroidism, seizures, Parkinsons disease or an obstruction of the urinary tract. Before having surgery with a general anesthetic, tell the doctor or dentist about the use of carbachol. Do not allow anyone else to use this medication. It is classified as pregnancy category C and should be used during pregnancy or lactation only if clearly needed.

Available Brands

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Single Ingredient

Inj

0.1 mg/ml

Storage Conditions

Carbachol should be stored Eye Drops.

Drug Classification

1.21.4.1 — Miotics

Manufacturers

Manufacturers of Carbachol in Pakistan:

Ethical Farmigea Novartis Ophth-Pharma