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Calcipotriol

Also known as: Calcipotriene, Calcipotriolum

Drug #830

Calcipotriol is a synthetic analogue of vitamin D, a fat soluble sterol, sometimes considered to be hormone or hormone precursor. Calcipotriol is involved in promoting normal bone development in body by regulating calcium, phosphorus and minerals. Vitamin D is a secosteroid and sometimes popularly known as the 'sunshine vitamin' because formed in the skin from 7-dehydrocholesterol under the influence of ultraviolet irradiation. Calcipotriol is also found in certain food. Fish liver oils, especially code liver oil are good sources of vitamin D. Calipotriol effects cell division and differentiation. At the cellular level the action of calcipotriol is very similar preparation for psoriosis to that of the natural hormones calcitriol or 1, 25 dihydroxy Vit D where or its systemic effects on Ca.

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Primary Characteristics

Calcipotriol is also known as Calcipotriene, Calcipotriolum.

It is of Natural origin and belongs to Vitamin D3.

It is classified in Antiposriasis pharmacological group. It is also classified under Dermatological Products .

Molecular Weight: 412.6 · pKa: 15-29 · Solubility in Water: null · Solubility in Alcohol: 1-3 · Non-proprietary name: Calcipotriol.

Molecular structure of Calcipotriol

Pharmacokinetics

Elimination: it is metabolised via hepatic.

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Indications

Calcipotriol is primarily indicated in conditions like Plaque psoriasis, Psoriasis vulgaris, Scalp psoriasis.

Contraindications

Calcipotriol is contraindicated in conditions like Known disorder of calcium metabolism.

Dosage

Calcipotriol's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
0.005 %0.005 %Every 12hTopicalNo more than 100g ofcream or ointment of 60ml of scalp solution should be applied in 1 week if both are used than maximum 60gm of cream/ointment
Paediatric Dosage (20kg)
0 – 0———Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0——Not recommended in this age group

Drug Interactions

None recorded.

Side Effects

Calcipotriol in overdosage may give rise to further complications which include Photosensitivity , Hypercalcemia , Perioral dermatitis, Dry skin.

The signs and symptoms that are produced after acute overdosage of Calcipotriol are Hypercalcemia.

Calcipotriol is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Contact dermatitis, Erythema, Facial dermatitis, Fatigue, Headache, Hot flushes, Local irritation, Weakness, Weight LossX, Xerosis.

Warnings / Precautions

Calcipotriol should be used with caution in elderly. It should not be used in patients with disorder of calcium metabolism and with a history of hypersensitivity reactions. Ointment should not be used on the face since the ointment formulation may give rise to irritation of the facial skin. Careful hand washing after use is recommended. It is classified as pregnancy category C should be used only when the benefit of therapy outweighs the risk to fetus. It should be used with caution in generalized pustular or erythrodermic exfoliative psoriasis.Avoid use in face and excessive exposure to sun light and sunlamps.

Available Brands

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Single Ingredient

Cream
0.005 %w/w
Oint
0.005 %w/w

Multi-Ingredient Combinations

Oint
0.005 %w/w

Storage Conditions

Calcipotriol should be stored Oint.

Drug Classification

  1. 1.13.9 — Anti-psoriatics

Manufacturers

Manufacturers of Calcipotriol in Pakistan:

BiogenNabiqasimValorZam