Amisulpride

Drug #796

Amisulpride is oral anti-psychotic drug that acts by blocking presynaptic (in low doses) and postsynaptic (at high doses) dopamine receptors (D2 and D3). Amisulpride is used to control symptoms of schizophrenia. (a severe mental disorder associated with brain abnormalities and particularly evidenced by disorganized speech and behavior, elusions, and hallucinations).

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Primary Characteristics

It is of Synthetic origin and belongs to Benzamide.

It is also classified under Sedatives and Hypnotics .

Molecular Weight: 369.5 · Solubility in Water: 2.93e-01mg/mL · Solubility in Alcohol: null · Non-proprietary name: Amisulpride.

Pharmacokinetics

Distribution: Amisulpride has a plasma protein binding is 17%.

Elimination: plasma half-life is 12hrs.

Indications

Amisulpride is primarily indicated in conditions like Anxiety, Control of muscarinic side-effects of neostigmine, Depression, Peptic ulcer, Schizophrenia, Schizophrenia (acute psychotic episode), Schizophrenia (predominantly negative symptoms), Tourette's syndrome, Vertigo.

Contraindications

Amisulpride is contraindicated in conditions like Phaeochromocytoma, Hypomania, Porphyria.

Dosage

Amisulpride's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2.5 mg/kg	2.5 mg/kg	Every 24h	PO	-
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown3 interactions

4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

The signs and symptoms that are produced after acute overdosage of Amisulpride are Tachycardia , Coma, Convulsions , Restlessness .

Amisulpride is known to cause more or less tolerable side effects which are usually transient. These include Agitation , Overstimulation , Sleep disturbance.

Warnings / Precautions

Atypical antipsychotics (e.g Amisulpride) should be used with caution in patients with cardiovascular disease, or a history of epilepsy; it should be used with caution inelderly; while atypical antipsychotics (e.g Amisulpride) have not generally been associated with clinically significant prolongation of the QT interval, they should be used with care if prescribed with other drugs that increase QT interval. DRIVING: Drowsiness may affect performance of skilled tasks (e.g driving or operating machinery), especially at start of treatment; effects of alcohol are enhanced. WITHDRAWL: Withdrawl of antipsychotic drugs after long-term therapy should always be gradual and closely monitored to avoid the risk of acute withdrawl syndrome or rapid relapse.

Available Brands

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Single Ingredient

Tabs

100 mg 50 mg

Storage Conditions

Amisulpride should be stored Tab.

Drug Classification

1.24.1 — Drugs used in psychotic disorders

Manufacturers

Manufacturers of Amisulpride in Pakistan:

Genome