DrugInfoSys

Alfuzosin

Drug #787

Alfuzosin is a competitive antagonist at the a1 adrenergic receptor, used for symptomatic relief in benign prostatic hypertrophy. Alfuzosin is optically active quinazolone derivative prepared by chemical synthesis. The racemate is used clinically. Alfuzosin is administered orally.

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Primary Characteristics

It is of Synthetic origin and belongs to Furancarboxamide.

It belongs to Alpha-1 adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Selective 5-HT3 Receptor Antagonist pharmacological group.

Molecular Weight: 425.9 · pKa: 8.13 · Solubility in Water: freely soluble · Solubility in Alcohol: sparingly soluble · Non-proprietary name: Alfuzosin.

Molecular structure of Alfuzosin

Pharmacokinetics

Absorption: Alfuzosin has an oral bioavailability is 64%.

Distribution: Alfuzosin has a volume of distribution is 2.5 l/kg. plasma protein binding is 90%.

Elimination: it is metabolised via hepatic, plasma half-life is 3.5-5.5 hr, renal excretion is 11%.

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Indications

Alfuzosin is primarily indicated in conditions like Benign prostatic hyperplasia.

Alfuzosin is also indicated for secondary conditions like Hypertension.

Contraindications

Alfuzosin is contraindicated in conditions like Hypotension, Hepatic insufficiency, Hypersensitivity.

Dosage

Alfuzosin's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
6.25 mg6.25 mgEvery 8hPOMaximum 10mg/day.
10 mg10 mgEvery 24hPO10 mg/day as a single dose of modified release preparation. Take after meal.
Paediatric Dosage (20kg)
0 – 0———Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0——nnot recommended in this age group

Drug Interactions

1 interaction
Major3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Alfuzosin is known to cause more or less tolerable side effects which are usually transient. These include dizziness, Headache, Nausea, Postural hypotension, Skin rash, Syncope , Tachycardia, Vertigo, Vomiting .

Warnings / Precautions

To avoid first dose effect i.e. marked postural hypotension and syncope, initial dose should be reduced and to be taken at the bed time.

Available Brands

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Single Ingredient

Tabs
10 mg2.5 mg5 mg
Tabs SR
5 mg

Storage Conditions

Alfuzosin should be stored Tab.

Drug Classification

  1. 1.12.3.5 — Alpha-1 receptor antagonists

Manufacturers

Manufacturers of Alfuzosin in Pakistan:

AventisNabiqasimNovinsPulseWerrickWilsons