Phenoxybenzamine (HCl)
Phenoxybenzamine (HCl) is irreversible a-adrenergic blocking agent, with a non-selective, covalent biniding with both a1 post-synaptic and a2 presynaptic receptors.Chemically related to nitrogen mustard. it has a long duration of action. Phenoxybenzamine (HCl) is used to control hypertension and sweating in pheochromocytoma, to treat Raynaud`s phenomenon, to treat micturation disorders resulting from neurogenic bladder dysfunction.
Primary Characteristics
It is of Synthetic origin and belongs to Haloalkylamines.
It belongs to Alpha adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.
Molecular Weight: 340.3 · Solubility in Water: 1 in 25 · Solubility in Alcohol: 1 in 9 · Non-proprietary name: Phenoxybenzamine (HCl).
Pharmacokinetics
Absorption: Phenoxybenzamine (HCl) has an oral bioavailability is 105%.
Elimination: it is metabolised via Hepatic, plasma half-life is 24 hr.
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Indications
Phenoxybenzamine (HCl) is primarily indicated in conditions like Adjunct in hypertensive episodes in pheochromocytoma, Hypertension, Hypertensive episodes in phaeochromocytoma, Phaeochromocytoma.
Phenoxybenzamine (HCl) is also indicated for secondary conditions like Raynaud's phenomenon, Urinary obstruction.
Contraindications
Phenoxybenzamine (HCl) is contraindicated in conditions like Orthostatic hypotension, Fluid depletion.
Dosage
Phenoxybenzamine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1 mg/kg | 1 mg/kg | Every 24h | IV Inf | For atleast 2 hrs., As Required |
| 0.571 mg/kg | 0.571 mg/kg | Every 12h | PO | - |
| Paediatric Dosage (20kg) | ||||
| 0.75 mg/kg | 0.75 mg/kg | Every 12h | Oral | For Paeds of All Ages |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Phenoxybenzamine (HCl) in overdosage may give rise to further complications which include Postoperative hypotension .
Phenoxybenzamine (HCl) produces potentially life-threatening effects which include Postural hypotension. Careful monitoring is needed with proper medical management.
Phenoxybenzamine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Ejaculatory failure, Lethargy, Miosis , Nasal stiffiness, Nausea and vomiting, Sedation .
Warnings / Precautions
Interference in Pathology
Phenoxybenzamine (HCl) may interfere in the diagnosis of None well documented.
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.12.3.5 — Alpha-1 receptor antagonists