Temazepam
Temazepam is oral benzodiazepine used as a hypnotic agent in the short-term management of insomnia.Temazepam is often preferable to flurazepam for insomnia, particularly in the elderly or patients with liver disease, because it has a shorter half-life and does not have active metabolites. It was approved by the FDA in 1981.
Primary Characteristics
It is of Synthetic origin and belongs to Benzodiazepine.
It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Benzodiazepine pharmacological group. It is also classified under Sedatives and Hypnotics .
Molecular Weight: 300.7 · pKa: 1.6 · Solubility in Water: < 1 in 10000 · Solubility in Alcohol: 1 in 10 · Non-proprietary name: Temazepam.
Pharmacokinetics
Absorption: Temazepam has an oral bioavailability is 96.5% (±1.5%), pre-systemic (first-pass) metabolism accounts for 0.5% (±0.5%).
Distribution: Temazepam has a volume of distribution is 1.3 - 1.5 l/kg. plasma protein binding is 76 - 96 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 5.3 - 11.5 hr, renal excretion is 80 %.
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Indications
Temazepam is primarily indicated in conditions like Insomnia, Nausea, vertigo, labyrinthine disorders, Premedication before surgery.
Temazepam is also indicated for secondary conditions like Surgery.
Contraindications
Temazepam is contraindicated in conditions like Pulmonary insufficiency.
Dosage
Temazepam's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 25 mg | 25 mg | Every 24h | PO | At bed time. |
| Paediatric Dosage (20kg) | ||||
| 0.75 mg/kg | 0.75 mg/kg | — | Oral | As Required |
| Neonatal Dosage (3kg) | ||||
| 0.75 mg/kg | 0.75 mg/kg | — | Oral | As Required |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Temazepam in overdosage may give rise to further complications which include Hypotension , Blood dyscrasias , Jaundice .
Temazepam is known to cause more or less tolerable side effects which are usually transient. These include Nystagmus .
Warnings / Precautions
Interference in Pathology
Temazepam may interfere in the diagnosis of Abnormal LFTs .
Available Brands
Storage Conditions
Drug Classification
- 1.24.3 — Drugs used in anxiety and sleep disorders