DrugInfoSys

Suxamethonium (Cl)

Also known as: Succinylcholine Chloride Succinate

Drug #698

Suxamethonium (Cl) muscle relaxant. Suxamethonium (Cl) used as an adjunct to anesthesia for surgery. Suxamethonium (Cl) acts by depolarization of muscle end plate, rendering the tissue incapable of responding to the neurotransmitter. itrapid acting and has a short duration of action.

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Primary Characteristics

Suxamethonium (Cl) is also known as Succinylcholine Chloride Succinate.

It belongs to Acetylcholine.

It belongs to Cholinergic nicotinic antagonist pharmacological group on the basis of mechanism of action and also classified in Muscle Relaxants pharmacological group.

Molecular Weight: 361.3 · pKa: not relevant · Solubility in Water: 1 in 1 · Solubility in Alcohol: 1 in 350 · Non-proprietary name: Suxamethonium (Cl).

Molecular structure of Suxamethonium (Cl)

Pharmacokinetics

Elimination: it is metabolised via Plasma.

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Indications

Suxamethonium (Cl) is primarily indicated in conditions like Muscle relaxation (rapid onset, short duration), Muscular spasm, Neuromuscular blockade.

Suxamethonium (Cl) is also indicated for secondary conditions like Anesthesia, Insomnia, Surgery.

Contraindications

Suxamethonium (Cl) is contraindicated in conditions like Malignant hyperthermia, Myopathy, Eye injuries.

Dosage

Suxamethonium (Cl)'s dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
0.15 mg/ kg0.15 mg/ kg—IVUsually produce muscle relaxation for 1-3 Min.
Paediatric Dosage (20kg)
1 mg/kg1 mg/kg—IntravenousAs required
Neonatal Dosage (3kg)
2 mg/kg2 mg/kg—IntravenousAs required

Drug Interactions

Unknown34 interactions
4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Suxamethonium (Cl) in overdosage may give rise to further complications which include Increased intragastric pressure, Increased IOP (intraocular pressure).

Suxamethonium (Cl) produces potentially life-threatening effects which include Pulmonary edema , Respiratory depression, Hyperkalemia , Cardiac arrhythmias, Myalgia , Pulmonary hemorrhage, Myoglobinemia, Increased intracranial pressure, Increased intraocular pressure. Careful monitoring is needed with proper medical management.

Warnings / Precautions

Avoid suxamethazone in patients with burns, massive trauma, renal impairment, severe long lasting sepsis and severe hyperkalaemia, sensitivity to drug, eye injury or glaucoma. It should be used with caution in patients with bone fractures, cardiac or respiratory disease. Dose of neuromuscular blocking agent need to be clearly titrated for individual patients according to their response; monitoring of the degree of block is recommended in order to reduce the risk of overdosage. Patients who have received neuromuscular blocker should always have their respiration assisted or controlled until the drug has been inactivated or antagonized.

Interference in Pathology

Suxamethonium (Cl) may interfere in the diagnosis of Increased Serum Potassium Level.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj
100 mg/5ml100 mg/ml20 mg/ml50 mg/ml
Tabs
2 mg

Storage Conditions

Suxamethonium (Cl) should be stored Inj.

Drug Classification

  1. 1.20 — Muscle relaxants and cholinesterase inhibitors

Manufacturers