Aurothiomalate

Drug #66

Aurothiomalate is a parentrally administered preparation of Gold. Gold compounds were introduced for the treatment of rheumatoid arthritis in the 1920s. Aurothiomalate is administered intramuscularly as water soluble gold salt containing 50 % elemental gold. Gold therapy is indicated for active rheumatoid arthritis.

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Primary Characteristics

It is of Synthetic origin and belongs to Gold Compound.

It belongs to Immune Modifiers pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 2500 · pK_a: 3.2 · Solubility in Water: very soluble · Solubility in Alcohol: insoluble · Non-proprietary name: Aurothiomalate.

Pharmacokinetics

Absorption: Aurothiomalate has an oral bioavailability is 100%.

Distribution: Aurothiomalate has a volume of distribution is 0.1l/kg. plasma protein binding is 95%.

Elimination: plasma half-life is 132 hr, renal excretion is major.

Indications

Aurothiomalate is primarily indicated in conditions like Juvenile chronic arthritis, Palindromic rheumatism, Psoriatic arthritis, Rheumatoid arthritis.

Contraindications

Aurothiomalate is contraindicated in conditions like Bone marrow depression, Nephritis.

Dosage

Aurothiomalate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.714 mg/kg	0.714 mg/kg	—	IM	Once in a Week, For 5 Months
0.107 mg/kg	0.107 mg/kg	Every 24h	PO	Gradually Increased over 3 Months
Paediatric Dosage (20kg)
0.75 mg/kg	0.75 mg/kg	—	Intra Muscular	Initial, gradually increased
1 mg/kg	1 mg/kg	—	Intra Muscular	Maintenance per week for 6-8 Months
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Aurothiomalate in overdosage may give rise to further complications which include Renal damage , Musculoskeletal effects , Thrombocytopenia .

Aurothiomalate produces potentially life-threatening effects which include Bone marrow aplasia, Neutropenia , Pancytopenia . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Aurothiomalate are Nausea, Vomiting, Erythematous rash , Exfoliative dermatitis , Stomatitis, Pharyngitis, Tracheitis, Gastritis, Colitis, Vaginitis, BLood dyscrasias, Albuminuria, Hematuria, Acute renal failure, Encephalitis, Polyneuropathy, Jaundice .

Aurothiomalate is known to cause more or less tolerable side effects which are usually transient. These include Mouth ulcers, Skin RashX.

Warnings / Precautions

Do not use Penicillamine or antimalarial with gold salts such as aurothiomalate. Before initiating treatment rule out pregnancy, perform complete blood count, urine analysis, liver and renal function test. Use with caution in patients with compromised cardiovascular or cerebral circulation.

Available Brands

None recorded.

Storage Conditions

Aurothiomalate should be stored Inj.

Drug Classification

1.2.4 — Disease modifying antirheumatic drugs