Ritodrine (HCl)

Drug #651

Ritodrine (HCl) is a beta-2 agonist, relaxes the uterine smooth muscles. Ritodrine (HCl) is used to arrest uncomplicated premature labour between 24-33 weeks of gastationand it may permit a delay in delivery of at least 48 hours.

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Primary Characteristics

It is of Synthetic origin and belongs to Hydroxyphenylamide.

It belongs to Beta-2 adrenergic agonist pharmacological group on the basis of mechanism of action. It is also classified under Posterior Pituitary Hormones .

Molecular Weight: 323.8 · pK_a: 8.6 · Solubility in Water: > 1 in 10 · Solubility in Alcohol: >1 in 10 · Non-proprietary name: Ritodrine (HCl).

Pharmacokinetics

Absorption: Ritodrine (HCl) has an oral bioavailability is 96.5% (±1.5%), pre-systemic (first-pass) metabolism accounts for 65% (±5%).

Distribution: Ritodrine (HCl) has a volume of distribution is 0.6 - 0.9 l/kg. plasma protein binding is 30 %.

Elimination: plasma half-life is 1.7 - 2.6 hr, renal excretion is 90 %.

Indications

Ritodrine (HCl) is primarily indicated in conditions like Asphyxia, Oedema, Oliguria due to renal failure, Premature labour, Uncomplicated premature labor.

Contraindications

Ritodrine (HCl) is contraindicated in conditions like Hyperthyroidism, Heart disease, Ecg abnormalities, Eclampsia, Chorioamnionitis, Cord compression, Intrauterine fetal death, Antepartum haemorrhage.

Dosage

Ritodrine (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
15 mg	15 mg	Every 6h	IM	For 2 Days
0.71 ug/ kg.min	0.71 ug/ kg.min	—	IV Inf	Initially as required
3.57 ug/ kg.min	3.57 ug/ kg.min	—	IV Inf	Maintenance for 12-48 Hours
10 mg	10 mg	Every 4h	PO	As Required
Paediatric Dosage (20kg)
0 – 0	—	—		Not indicated in children
Neonatal Dosage (3kg)
0 – 0	—	—		Not used in this age group

Drug Interactions

Unknown1 interaction

7 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Ritodrine (HCl) in overdosage may give rise to further complications which include Hyperlipidemic effects , Hyperglycemia , Metabolic disturbances , Hypokalemia , Hyperinsulinemia.

Ritodrine (HCl) produces potentially life-threatening effects which include Pulmonary edema , Cardiac arrhythmia, Cardiopulmonary complications, Angina-like complaints, Maternal death. Careful monitoring is needed with proper medical management.

Ritodrine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Anxiety, Erythema, Headache, Nausea and vomiting, Palpitation, Restlessness, Tremors.

Warnings / Precautions

Ritodrine should be used with caution in patients with hyperthyroidism, myocardial insufficiency, arrhythmias, hypertension and diabetes mellitus. It should be used with extreme caution during pregnancy.

Interference in Pathology

Ritodrine (HCl) may interfere in the diagnosis of Elevations of SGPT and SGOT , Elevation in ALT or AST.

Available Brands

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Single Ingredient

Inj

10 mg/5ml 10 mg/ml

Tabs

10 mg

Storage Conditions

Ritodrine (HCl) should be stored Inf. Inj.

Drug Classification

1.22.1.2 — Anti-oxytocics

Manufacturers

Manufacturers of Ritodrine (HCl) in Pakistan:

Highnoon Saffron